W. Fukumoto
10 Papers
W. Fukumoto is an academic researcher. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 2, co-authored 7 publications.
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Papers
microRNA‐99a‐5p induces cellular senescence in gemcitabine‐resistant bladder cancer by targeting SMARCD1
M. Tamai,Shuichi Tatarano,Shunsuke Okamura,W. Fukumoto,I. Kawakami,Yoichi Osako,Takashi Sakaguchi,Satoshi Sugita,Masaya Yonemori,Yasutoshi Yamada,Masayuki Nakagawa,Hideki Enokida,Hirofumi Yoshino +12 more
TL;DR: Tumor‐suppressive miR‐99a‐5p induced cellular senescence in gemcitabine‐resistant bladder cancer cells by targeting SMARCD1, and suppression of cell functions and restoration of gem citabine sensitivity was revealed.
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Exosomal microRNA-1 and MYO15A as a target for therapy and diagnosis in renal cell carcinoma.
Hirofumi Yoshino,Shuichi Tatarano,M. Tamai,Masafumi Tsuruda,Sayaka Iizasa,Junya Arima,I. Kawakami,W. Fukumoto,Ichiro Kawahara,Li Gang,Takashi Sakaguchi,Satoru Inoguchi,Yasutoshi Yamada,Hideki Enokida +13 more
TL;DR: In this article , the authors investigated the function of exosomal miR-1 and the possibility that the exosome constitutes a tumor maker in renal cell carcinoma (RCC) and established the method to collect exosomes from cell lysates and human serum by a spin column-based method.
18
Potential therapeutic target secretogranin II might cooperate with hypoxia-inducible factor 1α in sunitinib-resistant renal cell carcinoma.
W. Fukumoto,Hirofumi Yoshino,Shin-ichi Horike,Issei Kawakami,M. Tamai,Junya Arima,Ichiro Kawahara,Akihiko Mitsuke,Takashi Sakaguchi,Satoru Inoguchi,Makiko Meguro-Horike,Shuichi Tatarano,Hideki Enokida +12 more
TL;DR: SCG2 could be associated with sunitinib resistance through VEGF regulation in RCC cells through direct interaction between SCG2 and hypoxia‐inducible factor 1α (HIF1α) and coimmunoprecipitation assays revealed a direct interaction with HIF1 α.
5
Mp14-17 smarcd1 regulated by microrna-99a-5p contributes to gemcitabine resistance in bladder cancer via suppression of cellular senescence
Junya Arima,Hirofumi Yoshino,Ichiro Kawahara,W. Fukumoto,I. Kawakami,M. Tamai,Shuichi Tatarano,Hideki Enokida +7 more
TL;DR: Wang et al. as discussed by the authors found that miR-99a-5p overexpression or SMARCD1 down regulation induced cellular senescence with recovery of gemcitabine sensitivity.