W. Fraser Symmans
University of Texas MD Anderson Cancer Center
290 Papers
1.1K Citations
W. Fraser Symmans is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 71, co-authored 184 publications. Previous affiliations of W. Fraser Symmans include University of Münster.
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Papers
Abstract A066: Machine learning elucidates biology of response within and outside the mechanisms of action of therapeutic agents in the I-SPY2 breast cancer TRIAL
Rosalyn W. Sayaman,Denise M. Wolf,Christina Yau,Julia D. Wulfkhule,Emanuel F. Petricoin,Lamorna Brown Swigart,Tam Binh V Bui,Gillian L. Hirst,Diane Heditsian,W. Fraser Symmans,Angela DeMichele,Mark LaBarge,Laura J. Esserman,Laura J. van't Veer +13 more
TL;DR: This study identifies mechanism of action biomarkers associated with response to each drug and elucidates possible off-target effects contributing to observed drug sensitivity and resistance.
I-SPY2 endocrine optimization pilot (EOP): Neoadjuvant lasofoxifene (Laso) in molecularly selected patients with hormone receptor positive (HR+)/HER2 negative (HER2-) stage 2/3 breast cancer (BC).
M. Wei,Anthony D. Elias,Karthik V Giridhar,Matthew P. Goetz,Rita A Mukhtar,C. Vaklavas,Laura J. van't Veer,Silver Alkhafaji,Gillian L. Hirst,Hope S. Rugo,Nan Chen,W. Fraser Symmans,Alexander Borowsky,Lamorna Brown Swigart,Natsuko Onishi,Douglas Yee,Nola Hylton,L. Esserman,Jo Chien +18 more
Abstract PS4-01: Predictor of benefit from dose-dense paclitaxel chemotherapy for patients with hormone receptor-positive HER2-negative breast cancer. A GEICAM/9906 sub-study
Miguel Martín,Álvaro Rodríguez-Lescure,Lourdes Calvo,Manuel Ruiz-Borrego,Noelia Martínez-Jañez,Emilio Alba,Kevin Tran,I. Fernandez,Isabel Álvarez,Miguel Ángel Seguí,Vicente Valero,A. Antón-Torres,Raquel Andrés,Kepa Amillano,J. J. Ponce-Lorenzo,Severina Domínguez Fernández,Jesús Herranz,Raúl Rincón,Rosalía Caballero,Ana Santaballa Bertrán,Angel Guerrero-Zotano,W. Fraser Symmans +21 more
Global gene expression changes during neoadjuvant chemotherapy for human breast cancer.
Thomas A. Buchholz,David N. Stivers,James Stec,Mark Ayers,Edward Clark,Andrew Bolt,Aysegul Sahin,W. Fraser Symmans,Kenneth R. Hess,Henry Mark Kuerer,Vicente Valero,Gabriel N. Hortobagyi,Lajos Pusztai +12 more
TL;DR: This is the first report to show global gene expression changes during chemotherapy in a human solid tumor and a remarkable diversity in transcriptional response was observed for individual cases.
Targeted Therapy in Breast Cancer The HER-2/neu Gene and Protein
Jeffrey S. Ross,Jeffrey S. Ross,Jonathan A. Fletcher,Kenneth J. Bloom,Gerald P. Linette,Gerald P. Linette,James Stec,W. Fraser Symmans,Lajos Pusztai,Gabriel N. Hortobagyi +9 more
TL;DR: A review of 80 published studies encompassing more than 25,000 patients designed to consider the relative advantages and disadvantages of the various methods of measuring HER-2/neu in clinical breast cancer specimens is presented in this paper.