W. Fraser Symmans
University of Texas MD Anderson Cancer Center
290 Papers
1.1K Citations
W. Fraser Symmans is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 71, co-authored 184 publications. Previous affiliations of W. Fraser Symmans include University of Münster.
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Papers
HER2 expression and efficacy of preoperative paclitaxel/FAC chemotherapy in breast cancer.
Fabrice Andre,Fabrice Andre,Chafika Mazouni,Cornelia Liedtke,Shu Wan Kau,Debby Frye,Marjorie C. Green,Ana M. Gonzalez-Angulo,W. Fraser Symmans,Gabriel N. Hortobagyi,Lajos Pusztai +10 more
TL;DR: HER2 overexpression is associated with higher rate of pCR to preoperative T/FAC chemotherapy regardless of ER status, and correlates with increased TOP2A and decreased MAP-tau expression in ER-positive cancers.
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The Neo-Bioscore Update for Staging Breast Cancer Treated With Neoadjuvant Chemotherapy: Incorporation of Prognostic Biologic Factors Into Staging After Treatment
Elizabeth A. Mittendorf,Jose Vila,Susan L. Tucker,Mariana Chavez-MacGregor,Benjamin Smith,W. Fraser Symmans,Aysegul A. Sahin,Gabriel N. Hortobagyi,Kelly K. Hunt +8 more
TL;DR: The Neo-Bioscore improves the previously validated CPS+EG staging system and allows its application in ERBB2-positive patients and is recommended that treatment response and biologic markers be incorporated into the American Joint Committee on Cancer staging system.
Higher parity and shorter breastfeeding duration
Shivani S. Shinde,Shivani S. Shinde,Michele R. Forman,Michele R. Forman,Henry Mark Kuerer,Kai Yan,Florentia Peintinger,Kelly K. Hunt,Gabriel N. Hortobagyi,Lajos Pusztai,W. Fraser Symmans +10 more
TL;DR: The combination of increased parity and shorter breastfeeding duration might increase the odds of the least differentiated triple‐negative breast cancer phenotype, theoretically because an expanded progenitor cell population from each pregnancy would incompletely differentiate postpartum.
102
Local, Regional, and Systemic Recurrence Rates in Patients Undergoing Skin-Sparing Mastectomy Compared With Conventional Mastectomy
Min Yi,Steven J. Kronowitz,Funda Meric-Bernstam,Barry W. Feig,W. Fraser Symmans,Anthony Lucci,Merrick I. Ross,Gildy Babiera,Henry Mark Kuerer,Kelly K. Hunt +9 more
TL;DR: The purpose of this study was to examine the rates of local, regional, and systemic recurrence, and survival in breast cancer patients who underwent skin‐sparing mastectomy or conventional mastectomy at this institution.
101
Accuracy of the Combination of Mammography and Sonography in Predicting Tumor Response in Breast Cancer Patients After Neoadjuvant Chemotherapy
Florentia Peintinger,Henry Mark Kuerer,Keith Anderson,Judy C. Boughey,Funda Meric-Bernstam,S. Eva Singletary,Kelly K. Hunt,Gary J. Whitman,Tanya W. Stephens,Aman U. Buzdar,Marjorie C. Green,W. Fraser Symmans +11 more
TL;DR: Multivariate analysis showed that pathologic residual tumor size was underestimated for lobular carcinoma and overestimated for poorly differentiated tumors, and the combination of mammography and sonography has a high accuracy in predicting pCR after neoadjuvant chemotherapy.
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