Volker Knecht
University of Freiburg
53 Papers
577 Citations
Volker Knecht is an academic researcher from University of Freiburg. The author has contributed to research in topics: Chemistry & POPC. The author has an hindex of 22, co-authored 52 publications. Previous affiliations of Volker Knecht include Max Planck Society.
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Papers
Molecular Dynamics Simulations of Lipid Vesicle Fusion in Atomic Detail
TL;DR: Molecular dynamics simulations have been used to study the fusion of small unilamellar vesicles composed of a dipalmitoyl-phosphatidylcholine (DPPC)/palmitic acid 1:2 mixture in atomic detail and opens the perspective to study a wide variety of mesoscopic biological processes in Atomic detail.
166
Electrical Forces Determine Glomerular Permeability
Ralf Hausmann,Christoph Kuppe,Herbert Egger,Frank Schweda,Volker Knecht,Marlies Elger,Sylvia Menzel,Douglas Somers,Gerald S. Braun,Astrid Fuss,Sandra Uhlig,Wilhelm Kriz,George A. Tanner,Jürgen Floege,Marcus J. Moeller +14 more
TL;DR: A mathematical model is proposed that considers the relative contributions of diffusion, convection, and electrophoretic effects on the total flux of albumin across the filter and provides a unique approach to the microanatomy of the glomerulus, renal autoregulation, and the pathogenesis of proteinuria.
69
Simulation studies of pore and domain formation in a phospholipid monolayer
TL;DR: VSFG measurements may represent a sensitive means to determine the onset of the liquid-gas (G) coexistence region for such systems, and changes in order within the monolayer as a function of area density correlate well with the experimental signal.
Energetic basis for drug resistance of HIV-1 protease mutants against amprenavir
Parimal Kar,Volker Knecht +1 more
TL;DR: The results reveal that the protonation state of Asp25/Asp25′ strongly affects the dynamics, the overall affinity and the interactions of the inhibitor with individual residues, and may assist in the design of new inhibitors against HIV-1 PR variants that are resistant against current drugs.
61
Origin of Decrease in Potency of Darunavir and Two Related Antiviral Inhibitors against HIV-2 Compared to HIV-1 Protease
Parimal Kar,Volker Knecht +1 more
TL;DR: The popular molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) method has been used to investigate the effectiveness of the HIV-1 PR inhibitors darunavir, GRL-06579A, and G RL-98065 against HIV-2 and HIV- 1 protease, and shows that all these inhibitors bind less strongly to HIV- 2 than to HIV -1 protease.
56