Volkan Coskun
University of California, Los Angeles
10 Papers
18 Citations
Volkan Coskun is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Cellular differentiation & Biology. The author has an hindex of 9, co-authored 10 publications. Previous affiliations of Volkan Coskun include Semel Institute for Neuroscience and Human Behavior.
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Papers
Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes
Hao Wu,Volkan Coskun,Jifang Tao,Wei Xie,Weihong Ge,Kazuaki Yoshikawa,En Li,Yi Zhang,Yi E. Sun,Yi E. Sun +9 more
TL;DR: Genome-wide analysis of postnatal NSCs indicates that Dnmt3a occupies and methylates intergenic regions and gene bodies flanking proximal promoters of a large cohort of transcriptionally permissive genes, many of which encode regulators of neurogenesis and may be used for maintaining active chromatin states of genes critical for development.
A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis
Fei He,Weihong Ge,Keri Martinowich,Sara G. Becker-Catania,Sara G. Becker-Catania,Volkan Coskun,Wenyu Zhu,Hao Wu,Diogo S. Castro,François Guillemot,Guoping Fan,Jean de Vellis,Yi E. Sun +12 more
TL;DR: It is reported that the overall activity of Jak-STAT signaling is dynamically regulated in mouse cortical germinal zone during development, and observations suggest that autoregulation of the Jak- STAT pathway controls the onset of astrogliogenesis.
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Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells
Yuping Luo,Yuping Luo,Volkan Coskun,Aibing Liang,Juehua Yu,Liming Cheng,Weihong Ge,Zhanping Shi,Kunshan Zhang,Chun Li,Yaru Cui,Haijun Lin,Dandan Luo,Junbang Wang,Connie H. Lin,Zachary Dai,Hongwen Zhu,Jun Zhang,Jie Liu,Hailiang Liu,Jean deVellis,Steve Horvath,Yi E. Sun,Siguang Li +23 more
TL;DR: This study revealed the existence of dormant ependymal NSCs throughout the ventricular surface of the CNS, as well as signals abundant after injury for their activation, through single-cell transcriptome and weighted gene co-expression network analysis.
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Spatiotemporally different origins of NG2 progenitors produce cortical interneurons versus glia in the mammalian forebrain
TL;DR: This study indicates that early NG2 progenitors from a ventral origin tangentially migrate out of the medial ganglionic eminence and give rise to interneurons in deep layers of the dorsal cerebral cortex and define the relationship between lineage divergence and spatiotemporal origins.
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Epigenetic regulation of stem cells differentiating along the neural lineage.
TL;DR: Collectively, a complex epigenetic network formed by H3K4me3, histone acetylation/deacetylation, H 3K27me3 and DNA methylation/demethylation act together to regulate stem cell self-renewal and differentiation.
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