Vitina Sozzi
Royal Melbourne Hospital
18 Papers
13 Citations
Vitina Sozzi is an academic researcher from Royal Melbourne Hospital. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 6, co-authored 18 publications.
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Papers
Hepatitis B virus sensitivity to interferon‐α in hepatocytes is more associated with cellular interferon response than with viral genotype
Fang Shen,Fang Shen,Yaming Li,Yang Wang,Vitina Sozzi,Peter Revill,Jiangxia Liu,Lu Gao,Guang Yang,Mengji Lu,Kathrin Sutter,Ulf Dittmer,Jieliang Chen,Zhenghong Yuan +13 more
TL;DR: In the cell–culture–based HBV infection models, the sensitivity of HBV to IFN‐α in hepatocytes is determined more by the cell‐intrinsic IFN response than by viral genotype, and improvement of theIFN response in HepG2‐NTCP cells promotes the efficacy of IFN•α against HBV.
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Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B
Julianne Bayliss,Lilly Yuen,Gillian Rosenberg,Darren Wong,Darren Wong,Margaret Littlejohn,Kathleen Jackson,Anuj Gaggar,Kathryn M. Kitrinos,G. Mani Subramanian,Patrick Marcellin,Maria Buti,Harry L.A. Janssen,Edward Gane,Vitina Sozzi,Danni Colledge,R. Hammond,Rosalind Edwards,Stephen Locarnini,Alexander J. Thompson,Peter Revill +20 more
TL;DR: Patients with detectable BCP and/or PC variants and higher viral diversity have a lower probability of HBsAg loss during long-term NA therapy, and strategies to achieve functional cure of HBV infection should consider using NGS to stratify patients according to BCP/PC sequence.
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In vitro studies identify a low replication phenotype for hepatitis B virus genotype H generally associated with occult HBV and less severe liver disease.
Vitina Sozzi,Fang Shen,Jieliang Chen,Danni Colledge,Kathy Jackson,Stephen Locarnini,Zhenghong Yuan,Peter Revill +7 more
TL;DR: Genotype H exhibited reduced viral replication and altered envelope protein expression compared to genotype D, with functional studies showing that low replication was in part likely due to sequence differences in the major transcriptional regulatory region.
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Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype
Wen-Peng Li,Nadia Warner,Vitina Sozzi,Lilly Yuen,Danni Colledge,Tong Li,Hui Zhuang,Stephen Locarnini,Peter Revill +8 more
TL;DR: The identification of secretion-defective HBV in the setting of ADV therapy for HBV genotype C, and to a lesser extent HBVgenotype B, has major implications for the diagnosis and treatment of HBVs in the Asia-Pacific region, as it is likely that quantitative HBsAg and viral load testing of serum from patients infected with HBV encoding rtA181T and rtN236T substitutions may not accurately reflect the level of replication within hepatocytes.
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Molecular characterization of hepatitis B virus (HBV) in African children living in Australia identifies genotypes and variants associated with poor clinical outcome.
Elizabeth G Bannister,Elizabeth G Bannister,Elizabeth G Bannister,Lilly Yuen,Margaret Littlejohn,Rosalind Edwards,Vitina Sozzi,Danni Colledge,Xin Li,Stephen Locarnini,Winita Hardikar,Winita Hardikar,Peter Revill,Peter Revill +13 more
TL;DR: The profile of HBV in African children living in Australia was characterized by early HBeAg seroconversion and infection with HBV variants associated with poor clinical outcome, as well as genotypes previously associated with reduced vaccine efficacy or rapid progression to liver cancer.
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