Vipul Kumar
Howard Hughes Medical Institute
10 Papers
12 Citations
Vipul Kumar is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: V(D)J recombination & Non-homologous end joining. The author has an hindex of 5, co-authored 10 publications. Previous affiliations of Vipul Kumar include Harvard University & Boston Children's Hospital.
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Papers
Functional overlaps between XLF and the ATM-dependent DNA double strand break response
TL;DR: Current knowledge of the mechanisms that contribute to the repair of DSBs generated during B lymphocyte development and activation are discussed with a focus on potential functionally redundant roles of XLF and ATM-dependent DSBR factors.
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DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions.
Rohit A. Panchakshari,Rohit A. Panchakshari,Xuefei Zhang,Xuefei Zhang,Vipul Kumar,Vipul Kumar,Zhou Du,Zhou Du,Pei-Chi Wei,Pei-Chi Wei,Jennifer Kao,Jennifer Kao,Junchao Dong,Junchao Dong,Frederick W. Alt,Frederick W. Alt +15 more
TL;DR: It is shown that, when certain components of the DNA damage response pathway are inactivated, B-cell CSR junctions show different molecular signatures, indicating that they are repaired by a less-efficient alternative DNA repair pathway instead of the normal general cellular DNA break repair pathway.
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Ku70 suppresses alternative end joining in G1-arrested progenitor B cells.
Zhuoyi Liang,Zhuoyi Liang,Vipul Kumar,Vipul Kumar,Marie Le Bouteiller,Jeffrey Zurita,Jeffrey Zurita,Josefin Kenrick,Sherry G. Lin,Sherry G. Lin,Jiangman Lou,Jiangman Lou,Jianqiao Hu,Jianqiao Hu,Adam Yongxin Ye,Adam Yongxin Ye,Cristian Boboila,Cristian Boboila,Frederick W. Alt,Frederick W. Alt,Richard L. Frock +20 more
TL;DR: In this paper, the authors showed that a-EJ of DSB ends generated by RAG1/2, Cas9:gRNA, and Zinc finger endonucleases in Lig4-deficient G1-arrested progenitor B cell lines is suppressed by Ku.
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NHEJ and Other Repair Factors in V(D)J Recombination
Vipul Kumar,Frederick W. Alt +1 more
- 01 Jan 2016
TL;DR: The classical nonhomologous end-joining (C-NHEJ) pathway is discussed in the context of the V(D)J recombination reaction, which absolutely requires C-N HEJ for DSB repair and contributes to the diversity of antigen receptor molecules through the processing of DNA DSBs prior to their repair.
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Reprint of "Functional overlaps between XLF and the ATM-dependent DNA double strand break response".
TL;DR: Current knowledge of the mechanisms that contribute to the repair of DSBs generated during B lymphocyte development and activation are discussed with a focus on potential functionally redundant roles of XLF and ATM-dependent DSBR factors.
7