Viola Caretti
Stanford University
19 Papers
73 Citations
Viola Caretti is an academic researcher from Stanford University. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 11, co-authored 17 publications. Previous affiliations of Viola Caretti include VU University Medical Center.
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Papers
Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.
Humsa S. Venkatesh,Tessa Johung,Viola Caretti,Alyssa Noll,Yujie Tang,Surya Nagaraja,Erin M. Gibson,Christopher Mount,Jai S. Polepalli,Siddhartha Mitra,Pamelyn Woo,Robert C. Malenka,Hannes Vogel,Markus Bredel,Parag Mallick,Michelle Monje +15 more
TL;DR: Findings indicate the important role of active neurons in the brain tumor microenvironment and identify secreted NLGN3 as an unexpected mechanism promoting neuronal activity-regulated cancer growth.
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Subventricular spread of diffuse intrinsic pontine glioma.
Viola Caretti,Marianna Bugiani,Morgan E. Freret,Pepijn Schellen,Marc H. A. Jansen,Dannis G. van Vuurden,Gertjan J.L. Kaspers,Paul G. Fisher,Esther Hulleman,Pieter Wesseling,Pieter Wesseling,Hannes Vogel,Michelle Monje +12 more
TL;DR: Subventricular tumor spread is shown in the majority of patients, typically later in the course of their disease, as future therapies evolve to control local disease, strategies including extended or whole brain irradiation may become crucial as therapies improve and patients survive longer in the natural history of their cancer.
Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma
Amir Avan,Viola Caretti,Niccola Funel,Elena Galvani,Mina Maftouh,Richard J. Honeywell,Tonny Lagerweij,Olaf van Tellingen,Daniela Campani,Dieter Fuchs,Henk M.W. Verheul,Gerrit-Jan Schuurhuis,Ugo Boggi,Godefridus J. Peters,Thomas Wurdinger,Elisa Giovannetti +15 more
TL;DR: Four orthotopic mouse models using primary human PDAC cells genetically engineered to express firefly- and Gaussia luciferase are developed, simplifying the ability to monitor tumor growth and metastasis longitudinally in individual animals with MRI and high-frequency ultrasound and pointing to c-Met as a candidate therapeutic target in PDAC.
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WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas
Viola Caretti,Lotte Hiddingh,Tonny Lagerweij,Pepijn Schellen,Phil W. Koken,Esther Hulleman,Dannis G. van Vuurden,W. Peter Vandertop,Gertjan J.L. Kaspers,D. P. Noske,Thomas Wurdinger +10 more
TL;DR: Results show that inhibition of WEE1 kinase in conjunction with radiotherapy holds potential as a therapeutic approach for the treatment of DIPG.
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Role of CYB5A in Pancreatic Cancer Prognosis and Autophagy Modulation
Elisa Giovannetti,Qiuyan Wang,Amir Avan,Niccola Funel,Tonny Lagerweij,Jih-Hsiang Lee,Viola Caretti,Arjan van der Velde,Ugo Boggi,Yisong Wang,Enrico Vasile,Godefridus J. Peters,Thomas Wurdinger,Giuseppe Giaccone +13 more
TL;DR: CYB5A is defined as a novel prognostic factor for PDAC that exerts its tumor-suppressor function through autophagy induction and TRAF6 modulation and causes reduced proliferation and migration/invasion of PDAC cells.
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