Vinod Kumar
University of Nebraska Medical Center
7 Papers
Vinod Kumar is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Hepatic stellate cell & Chemistry. The author has an hindex of 6, co-authored 7 publications.
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Papers
Impact of miRNA-mRNA Profiling and Their Correlation on Medulloblastoma Tumorigenesis
Vinod Kumar,Virender Kumar,Amit Kumar Chaudhary,Don W. Coulter,Timothy R. McGuire,Ram I. Mahato +5 more
TL;DR: Functional analysis revealed that the inhibition of miR-217 in HDMB03 cells suppresses colony formation, migration, invasion, promoted apoptosis, and arrested cell population in S phase, indicating that manipulation of miD-217 may have a therapeutic potential for MB patients.
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Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer
Vinod Kumar,Amit Kumar Chaudhary,Yuxiang Dong,Haizhen A. Zhong,Goutam Mondal,Feng Lin,Virender Kumar,Ram I. Mahato +7 more
TL;DR: The design, synthesis and evaluation of novel GDC-0449 analogs using N-[3-pyridinyl) phenyl] benzamide scaffold highlight the enhanced Hh pathway inhibition and anticancer properties of MDB5 leaving a platform for mono and/or combination therapy.
The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis.
TL;DR: This study provides evidence that MDB5 was more potent in inhibiting Hh pathway in HSC-T6 cells and showed better hepatoprotection in CBDL mice compared to GDC-0449.
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Therapeutic Potential of OMe-PS-miR-29b1 for Treating Liver Fibrosis.
TL;DR: Micellar delivery of OMe-PS-miR-29b1 is a promising strategy to treat liver fibrosis and shows the highest stability with low immunogenicity, without the loss of efficacy in vitro.
Redox-responsive nanoplatform for codelivery of miR-519c and gemcitabine for pancreatic cancer therapy
Xiaofei Xin,Virender Kumar,Feng Lin,Vinod Kumar,Rajan Sharma Bhattarai,Vijaya Raj Bhatt,Chalet Tan,Ram I. Mahato +7 more
TL;DR: In this article, the authors demonstrated that miR-519c was downregulated in pancreatic cancer and transfection of miR519c in GEM-resistant pancreatic cells inhibited HIF-1α level under hypoxia.