Vincenzo Di Marzo
Laval University
709 Papers
4.8K Citations
Vincenzo Di Marzo is an academic researcher from Laval University. The author has contributed to research in topics: Endocannabinoid system & Cannabinoid receptor. The author has an hindex of 126, co-authored 659 publications. Previous affiliations of Vincenzo Di Marzo include National Research Council & University of Siena.
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Papers
Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB1 receptors
Giovanni Appendino,Alessia Ligresti,Alberto Minassi,Nives Daddario,Tiziana Bisogno,Vincenzo Di Marzo +5 more
TL;DR: The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB(1) receptors.
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Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): the homovanillyl moiety.
Giovanni Appendino,Abdellah Ech-Chahad,Alberto Minassi,Sara Bacchiega,Luciano De Petrocellis,Vincenzo Di Marzo +5 more
TL;DR: The ROPA motif provided an enhancement of potency sufficient to expand the range of vanillyl surrogates to structural elements that afford inactive analogues in compounds from the capsaicin series.
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Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders.
Jordi Tomas-Roig,Fabiana Piscitelli,Vanesa Gil,Ester Quintana,Lluís Ramió-Torrentà,José Antonio del Río,Timothy Patrick Moore,Hope Agbemenyah,Gabriela Salinas,Claudia Pommerenke,Stephan Lorenzen,Stephan Lorenzen,Tim Beißbarth,Sigrid Hoyer-Fender,Vincenzo Di Marzo,Ursula Havemann-Reinecke +15 more
TL;DR: A psychosocial stress model based on resident‐intruder confrontations is used to study the brain corticostriatal‐function and CB1 receptors are widely expressed in the central nervous system and particularly, in both cortex and striatum brain structures.
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Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes
Sarah Mazzotta,Sarah Mazzotta,Gabriele Carullo,Gabriele Carullo,Aniello Schiano Moriello,Pietro Amodeo,Vincenzo Di Marzo,Vincenzo Di Marzo,Margarita Vega-Holm,Rosa Maria Vitale,Francesca Aiello,Antonella Brizzi,Luciano De Petrocellis +12 more
TL;DR: This study represents the first report of semisynthetic homodrimane TRPV4 antagonists, selective overTRPV1, and potentially useful as pharmacological tools for the development of novel TRPv4 channel modulators.
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Synthesis and Biological Evaluation of Phorbol‐Resiniferatoxin (RTX) Hybrids
Giovanni Appendino,Andrea Bertolino,Alberto Minassi,Rita Annunziata,Arpad Szallasi,Luciano De Petrocellis,Vincenzo Di Marzo +6 more
TL;DR: In this article, the structure-activity relationships for vanilloid ligands were expanded, and several unexpected reactions were discovered, and the structure activity relationships for this class of vanilloids were expanded.
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