Vincenzo Di Marzo
Laval University
709 Papers
4.8K Citations
Vincenzo Di Marzo is an academic researcher from Laval University. The author has contributed to research in topics: Endocannabinoid system & Cannabinoid receptor. The author has an hindex of 126, co-authored 659 publications. Previous affiliations of Vincenzo Di Marzo include National Research Council & University of Siena.
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Papers
Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol
Tiziana Bisogno,James J. Burston,Ravi Rai,Marco Allarà,Bijali Saha,Anu Mahadevan,Raj K. Razdan,Jenny L. Wiley,Vincenzo Di Marzo +8 more
TL;DR: Biosynthesis Inhibition: O‐5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2‐arachidonoylglycerol, was synthesized and found to be potent and selective versus other proteins and enzymes of the Endocannabinoids system in vitro and active in vivo at reducing food intake in mice.
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Platelet-Rich Plasma Exerts Antinociceptive Activity by a Peripheral Endocannabinoid-Related Mechanism
Fiorella Descalzi,Valentina Ulivi,Ranieri Cancedda,Fabiana Piscitelli,Livio Luongo,Francesca Guida,Luisa Gatta,Sabatino Maione,Vincenzo Di Marzo +8 more
TL;DR: It is shown that PRP and PRP lipid extract exert a potent antinociceptive activity linked, at least in part, to their endocannabinoids and related compound content, and to their capability of elevating the levels of these lipid mediators in cells.
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Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: insulin and melanocortins.
Isabel Matias,Anna Valeria Vergoni,Stefania Petrosino,Alessandra Ottani,Alessandro Pocai,Alfio Bertolini,Vincenzo Di Marzo +6 more
TL;DR: Investigation in the rat if insulin, which is known to exert fundamental actions at the level of the mediobasal hypothalamus, and the melanocortin system, namely alpha-melanocyte stimulating hormone (alpha-MSH) and melanoc Cortin receptor-4 (MCR-4), also regulate hypothalamic endocannabinoid levels suggests stimulation of endoc cannabinoid levels might underlie part of the late stimulatory effects of M CR-4 blockade on food intake.
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Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro
Teresa Iuvone,Giuseppe Esposito,Daniele De Filippis,Tiziana Bisogno,Stefania Petrosino,Caterina Scuderi,Vincenzo Di Marzo,Luca Steardo +7 more
TL;DR: The data suggest that selective activation of CB1 receptors by either exogenous or endogenous cannabinoids might afford neuroprotection in MPTP-induced neurotoxicity also by controlling S100B up-regulation in activated glial cells.
Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.
Serena Boccella,Claudia Cristiano,Rosaria Romano,Monica Iannotta,Carmela Belardo,Antonio Farina,Francesca Guida,Fabiana Piscitelli,Enza Palazzo,Mariacristina Mazzitelli,Roberta Imperatore,Lea Tunisi,Vito de Novellis,Luigia Cristino,Vincenzo Di Marzo,Antonio Calignano,Sabatino Maione,Livio Luongo +17 more
TL;DR: It is suggested that neuropathic pain negatively affects cognitive behavior and related LTP, glutamatergic synapse and synaptogenesis in the DG, and PEA treatment alleviates pain and cognitive impairment by restoring LTP and synaptic maladaptative changes in the LEC-DG pathway.
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