Vincenzo Di Marzo
Laval University
709 Papers
4.8K Citations
Vincenzo Di Marzo is an academic researcher from Laval University. The author has contributed to research in topics: Endocannabinoid system & Cannabinoid receptor. The author has an hindex of 126, co-authored 659 publications. Previous affiliations of Vincenzo Di Marzo include National Research Council & University of Siena.
Chat about Author
Papers
N-Acylvanillamides: Development of an Expeditious Synthesis and Discovery of New Acyl Templates for Powerful Activation of the Vanilloid Receptor
Giovanni Appendino,Alberto Minassi,Aniello Schiano Morello,Luciano De Petrocellis,Vincenzo Di Marzo +4 more
TL;DR: Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that theVanilloid activity of capsaicinoids can be substantially improved by introducing polar groups and/or unsaturations on the acyl moiety.
69
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Natalia Malek,Monika Mrugala,Wioletta Makuch,Natalia Kolosowska,Barbara Przewlocka,Marcin Binkowski,Martyna Czaja,Enrico Morera,Vincenzo Di Marzo,Katarzyna Starowicz +9 more
TL;DR: OMDM-198 showed antihyperalgesic effects in the OA model, which were comparable with those of a selective TRPV1 antagonist, SB-366,791, and a selective FAAH inhibitor, URB-597, and these results suggest an innovative strategy for the treatment of OA, which may yield more satisfactory results than those obtained so far with selective FAAh inhibitors in human OA.
68
Behavioral and molecular changes elicited by acute administration of SR141716 to Δ9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence
Sara González,Javier Fernández-Ruiz,Vincenzo Di Marzo,Mariluz Hernández,Cristina Arévalo,Cristina Nicanor,Maria Grazia Cascio,Emilio Ambrosio,José A. Ramos +8 more
TL;DR: The data indicate that Delta(9)-THC-tolerant rats were not more vulnerable to the reinforcing properties of morphine and responded to the blockade of CB(1) receptors by exhibiting slightly but possibly relevant differences in behavioral, endocrine and molecular parameters compared to the response in non-tolerance rats.
67
A structure–activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase
Maria Grazia Cascio,Alberto Minassi,Alessia Ligresti,Giovanni Appendino,Sumner Burstein,Vincenzo Di Marzo +5 more
TL;DR: The view that an enhancement of endogenous anandamide levels underlies in part the analgesic effects of NAGly in rodents is supported.
67
Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists
Giovanni Appendino,Selena Harrison,Luciano De Petrocellis,Nives Daddario,Federica Bianchi,Aniello Schiano Moriello,Marcello Trevisani,Francesca Benvenuti,Pierangelo Geppetti,Vincenzo Di Marzo +9 more
TL;DR: 6‐iodo‐nordihydrocapsaicin, a stable and easily prepared compound, is a potent TRPV1 antagonist and a convenient replacement for capsazepine in most of the in vitro preparations currently used to assess the activity of putative vanilloid receptor agonists.