Vincenzo Di Marzo
Laval University
709 Papers
4.8K Citations
Vincenzo Di Marzo is an academic researcher from Laval University. The author has contributed to research in topics: Endocannabinoid system & Cannabinoid receptor. The author has an hindex of 126, co-authored 659 publications. Previous affiliations of Vincenzo Di Marzo include National Research Council & University of Siena.
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Papers
Endocannabinoid system and mood disorders: priming a target for new therapies.
TL;DR: The state of the art of the possible therapeutic use of endocannabinoid deactivation inhibitors and phytocannabinoids in mood disorders is discussed in this review article.
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A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease.
Mario van der Stelt,Susan H. Fox,Michael Hill,Alan R. Crossman,Stefania Petrosino,Vincenzo Di Marzo,Jonathan M. Brotchie +6 more
TL;DR: It is shown that signaling by endocannabinoids contributes to the pathophysiology of parkinsonism and LID in MPTP‐lesioned, non‐human primate models of Parkinson's disease and the level of anandamide and 2‐arachidonyl glycerol throughout the basal ganglia is determined.
212
Cannabinoid CB1 Receptor Mediates Fear Extinction via Habituation-Like Processes
Kornelia Kamprath,Giovanni Marsicano,Jianrong Tang,Krisztina Monory,Tiziana Bisogno,Vincenzo Di Marzo,Beat Lutz,Carsten T. Wotjak +7 more
TL;DR: It is demonstrated that the cannabinoid CB1 receptor, which is crucially involved in fear extinction, is dispensable for associative safety learning and indicated that CB1 mediates fear extinction primarily via habituation-like processes.
211
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells.
Vincenzo Di Marzo,Dominique Melck,Pierangelo Orlando,Tiziana Bisogno,Orna Zagoory,Maurizio Bifulco,Zvi Vogel,Luciano De Petrocellis +7 more
TL;DR: It is shown that PEA potently enhances the anti-proliferative effects of AEA on human breast cancer cells (HBCCs), in part by inhibiting the expression of fatty acid amide hydrolase (FAAH), the major enzyme catalysing AEA degradation.
Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels.
Vincenzo Micale,Luigia Cristino,Alessandra Tamburella,Stefania Petrosino,Gian Marco Leggio,Filippo Drago,Vincenzo Di Marzo +6 more
TL;DR: Simultaneous ‘indirect’ activation of CB1 receptors following FAAH inhibition, and antagonism at TRPV1 receptors might represent a new therapeutic strategy against anxiety.
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