Vincenzo Di Marzo
Laval University
709 Papers
4.8K Citations
Vincenzo Di Marzo is an academic researcher from Laval University. The author has contributed to research in topics: Endocannabinoid system & Cannabinoid receptor. The author has an hindex of 126, co-authored 659 publications. Previous affiliations of Vincenzo Di Marzo include National Research Council & University of Siena.
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Papers
Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo.
Tiziana Bisogno,Giorgio Ortar,Stefania Petrosino,Enrico Morera,Enza Palazzo,Marianna Nalli,Sabatino Maione,Vincenzo Di Marzo +7 more
TL;DR: OMDM69 might represent a template for the development of selective and even more potent inhibitors of 2-AG hydrolysis and the antinociceptive effect of OMDM169 was antagonized by antagonists of CB(1) and CB(2) receptors, AM251 and AM630, respectively.
Biochemistry and pharmacology of endovanilloids.
TL;DR: The mechanisms for the regulation of the levels of the proposed endovanilloids, as well as their TRPV1-mediated pharmacological actions in vitro and in vivo, are discussed and the possible pathological conditions in which endovanillsoids, acting at sometimes aberrantly expressed TRPv1 receptors, might play a role are outlined.
An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?
Cristina Avonto,Orazio Taglialatela-Scafati,Federica Pollastro,Alberto Minassi,Vincenzo Di Marzo,Luciano De Petrocellis,Giovanni Appendino +6 more
TL;DR: Research on Michael acceptors, long confined to the realm of toxicology, was rekindled by the development of the antioxidant inflammation modulator (AIM) homo-triterpenoid bardoxolone methyl.
The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation
TL;DR: The endocannabinoid system is quite widespread in mammalian tissues and cells and appears to play a pro-homeostatic role by being activated following transient or chronic perturbation of homeostasis, and by regulating in a local way the levels and action of other chemical signals.
Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis
Ana Maria Sanchez,Raffaella Cioffi,Paola Viganò,Massimo Candiani,Roberta Verde,Fabiana Piscitelli,Vincenzo Di Marzo,Elisabetta Garavaglia,Paola Panina-Bordignon +8 more
TL;DR: The association of increased circulating AEA and 2-AG with decreased local CB1 expression in endometriosis suggests a negative feedback loop regulation, which may impair the capability of these mediators to control pain.