Vincent Ries
University of Marburg
26 Papers
108 Citations
Vincent Ries is an academic researcher from University of Marburg. The author has contributed to research in topics: Substantia nigra & Dopamine. The author has an hindex of 15, co-authored 26 publications. Previous affiliations of Vincent Ries include University Hospital of Giessen and Marburg & Columbia University.
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Papers
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism.
Robert M. Silva,Vincent Ries,Tinmarla F. Oo,Olga Yarygina,Vernice Jackson-Lewis,Elizabeth J. Ryu,Phoebe D. Lu,Stefan M. Marciniak,David Ron,Serge Przedborski,Nikolai Kholodilov,Lloyd A. Greene,Robert E. Burke +12 more
TL;DR: The role of CHOP depends on the nature of the toxic stimulus, and for 6OHDA, an oxidative metabolite of dopamine, it is a mediator of apoptotic death.
A new dopaminergic nigro-olfactory projection
Günter U. Höglinger,Daniel Alvarez-Fischer,Oscar Arias-Carrión,Miriam Djufri,Andrea Windolph,Ursula Keber,Andreas Borta,Vincent Ries,Rainer K.W. Schwarting,Dieter Scheller,Wolfgang H. Oertel +10 more
TL;DR: It is demonstrated for the first time the existence of a direct dopaminergic projection into the olfactory bulb and its origin in the substantia nigra in rats, which may provide a neuroanatomical basis for invasion of environmental toxins into the basal ganglia and for hyposmia as frequent symptom in PD.
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JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.
Vincent Ries,Robert M. Silva,Tinmarla F. Oo,Hsiao-Chun Cheng,Margarita Rzhetskaya,Nikolai Kholodilov,Richard A. Flavell,Chia-Yi Kuan,Pasko Rakic,Robert E. Burke +9 more
TL;DR: It is found that homozygous jnk2/3 double null mutations result in a complete abrogation of apoptosis and a prolonged survival of the entire population of dopamine neurons, and the need to identify and target pathways of axon degeneration in the development of neuroprotective therapeutics is illustrated.
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Long-term treatment with l-DOPA or pramipexole affects adult neurogenesis and corresponding non-motor behavior in a mouse model of Parkinson's disease
Wei-Hua Chiu,Candan Depboylu,Guido Hermanns,Lukas Maurer,Andrea Windolph,Wolfgang H. Oertel,Vincent Ries,Günter U. Höglinger +7 more
TL;DR: It is found that l-DOPA and pramipexole can normalize decreased neurogenesis in the hippocampal dentate gyrus and the periglomerular layer of the olfactory bulb caused by a 6-OHDA lesion.
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Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B
Vincent Ries,Hsiao-Chun Cheng,Amy Baohan,Tatyana Kareva,Tinmarla F. Oo,Margarita Rzhetskaya,Ross J. Bland,Matthew J. During,Nikolai Kholodilov,Robert E. Burke +9 more
TL;DR: It is found that Akt regulates multiple features of the postnatal development of these neurons, including the magnitude of the apoptotic developmental cell death event, neuron size, and the extent of target innervation of the striatum.
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