Background: Pulmonary endothelial injury is a critical process in the pathogenesis of acute lung injury (ALI) during sepsis Heat shock protein A12B (HSPA12B) is

/pdf/heat-shock-protein-a12b-protects-vascular-endothelial-cells-3qj3tex105.pdf

Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice

2018 ESC/ESH Guidelines for the management of arterial hypertension.

Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Having a uniform standard for diagnosing and classifying AKI would enhance our ability to manage these patients. Future clinical and translational research in AKI will require collaborative networks of investigators drawn from various disciplines, dissemination of information via multidisciplinary joint conferences and publications, and improved translation of knowledge from pre-clinical research. We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI. Members representing key societies in critical care and nephrology along with additional experts in adult and pediatric AKI participated in a two day conference in Amsterdam, The Netherlands, in September 2005 and were assigned to one of three workgroups. Each group's discussions formed the basis for draft recommendations that were later refined and improved during discussion with the larger group. Dissenting opinions were also noted. The final draft recommendations were circulated to all participants and subsequently agreed upon as the consensus recommendations for this report. Participating societies endorsed the recommendations and agreed to help disseminate the results. The term AKI is proposed to represent the entire spectrum of acute renal failure. Diagnostic criteria for AKI are proposed based on acute alterations in serum creatinine or urine output. A staging system for AKI which reflects quantitative changes in serum creatinine and urine output has been developed. We describe the formation of a multidisciplinary collaborative network focused on AKI. We have proposed uniform standards for diagnosing and classifying AKI which will need to be validated in future studies. The Acute Kidney Injury Network offers a mechanism for proceeding with efforts to improve patient outcomes.

Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury

IMPORTANCE Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES To evaluate intensive ...

/pdf/epidemiology-patterns-of-care-and-mortality-for-patients-4fj7tqfkua.pdf

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk S50

The goals of the American College of Cardiology (ACC) and the American Heart Association (AHA) are to prevent cardiovascular diseases (CVD); improve the management of people who have these diseases through professional education and research; and develop guidelines, standards, and policies that promote optimal patient care and cardiovascular health. Toward these objectives, the ACC and AHA have collaborated with the National Heart, Lung, and Blood Institute (NHLBI) and stakeholder and professional organizations to develop …

/pdf/2013-acc-aha-guideline-on-the-assessment-of-cardiovascular-1t8hg65cmz.pdf

2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk

/pdf/conduite-a-tenir-devant-un-patient-porteur-d-une-ultej8c11h.pdf

Conduite à tenir devant un patient porteur d’une endoprothèse coronaire devant être anesthésié et opéré

Resume Objectif Verifier si les frequences cardiaques des patients prenant un traitement par betabloquants (BB) au long cours ou en peri-operatoire etaient optimales lors de la periode peri-operatoire. Methodes Les frequences cardiaques (FC) observees lors de la consultation d'anesthesie, avant l'induction d'anesthesie, et en peroperatoire (FC maximale et minimale) ont ete comparees chez trois groupes de patients repartis en fonction de la prise peri-operatoire de BB, de la prise chronique de BB, ou de l'absence de prise de BB. Les valeurs de FC sont exprimees sous forme de moyenne avec deviation standard. Resultats Au total, 406 patients ont ete inclus : 181 recevaient des BB de facon chronique, 20 ont beneficie d'une introduction preoperatoire et 205 ne prenaient pas de BB. Les FC des patients prenant des BB au long cours etaient plus basses que celles des patients du groupe temoin au repos (67 ± 11 vs 76 ± 12 b/min ; p  Conclusion Les ΒΒ prescrits une semaine avant l'intervention chirurgicale sont plus efficaces pour ralentir la FC que les BB administres de facon chronique.

Analyse des fréquences cardiaques durant la période péri-opératoire chez des patients prenant des bêtabloquants : réalité et efficacité du traitement

Wrong route medication errors due to tubing misconnections can lead to serious adverse events, especially when they concern the neuraxial and perineural routes. It has been favoured by the use of the universal Luer connector for medical devices with a risk of confusion with the intravenous route. The prevention of these errors is based on passive measures such as using specific small-bore connectors, and active measures such as reading Specific labelling which must be systematically affixed to the routes. NRFit connectors are a type of small-bore connector specifically intended for neuraxial and perineural applications. They are based on the International Organization for Standardization (ISO) standard 80369-6. They are physically incompatible with other small-bore connectors, like the Luer connectors used for intra-venous and enteral medication administration, and thus help prevent inadvertent misconnections. While some countries have already implemented this standard, France is behind schedule in implementing the NRFit connectors due to the absence of strong recommendations or obligations from the authorities. However, NRFit connectors represents real progress for the prevention of medication errors. 

[NRFit: a new standard to prevent wrong-route medication errors.]

Gestion péri-opératoire du patient traité par des antivitamines K

Stratégie d’optimisation de la prise en charge médicamenteuse péri-opératoire

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