Vincent Lu
University of Chicago
4 Papers
Vincent Lu is an academic researcher from University of Chicago. The author has contributed to research in topics: Nucleoporin & Protein subunit. The author has an hindex of 4, co-authored 4 publications.
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Papers
Architecture of the fungal nuclear pore inner ring complex
Tobias Stuwe,Christopher J. Bley,Karsten Thierbach,Stefan Petrovic,Sandra Schilbach,Daniel J. Mayo,Thibaud Perriches,Emily J. Rundlet,Young E. Jeon,Leslie N. Collins,Ferdinand M. Huber,Daniel H. Lin,Marcin Paduch,Akiko Koide,Vincent Lu,Jessica Fischer,Ed Hurt,Shohei Koide,Anthony A. Kossiakoff,André Hoelz +19 more
TL;DR: The reconstitution and interdisciplinary analyses of the ~425-kilodalton inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, are presented, revealing its interaction network and equimolar stoichiometry.
156
Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
Jian Sun,Marcin Paduch,Sang Ah Kim,Ryan M. Kramer,Adam F. Barrios,Vincent Lu,Judy Luke,Svitlana Usatyuk,Anthony A. Kossiakoff,Song Tan +9 more
TL;DR: Structural and biochemical results indicate that the Ada2 SANT domain does not activate Gcn5’s activity by directly affecting histone peptide binding as previously proposed, and suggests a mechanism for regulating chromatin modification enzyme activity: controlling binding of the modification cosubstrate instead of the histone substrate.
52
Architecture of the nuclear pore complex coat
Tobias Stuwe,Ana R. Correia,Daniel H. Lin,Marcin Paduch,Vincent Lu,Anthony A. Kossiakoff,André Hoelz +6 more
TL;DR: The crystal structure of a reconstituted ~400-kilodalton coat nucleoporin complex (CNC) from Saccharomyces cerevisiae is presented and revealed a curved Y-shaped architecture and the molecular details of the coat nucleiporin interactions forming the central “triskelion” of the Y.
Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins
Nan Zhong,Peter Loppnau,Alma Seitova,Mani Ravichandran,Maria Fenner,Harshika Jain,Anandi Bhattacharya,Ashley Hutchinson,Marcin Paduch,Vincent Lu,Michal Olszewski,Anthony A. Kossiakoff,Evan Dowdell,Akiko Koide,Shohei Koide,Haiming Huang,Vincent Nadeem,Sachdev S. Sidhu,Jack Greenblatt,Edyta Marcon,Cheryl H. Arrowsmith,Aled M. Edwards,Susanne Gräslund +22 more
TL;DR: A high-throughput project workflow to generate renewable recombinant antibodies to human proteins involved in epigenetic signalling is developed and it is shown that these Fabs and IgGs can be generally useful for chromatin immunoprecipitation (ChIP) protocols.