Vincent Jonchère
University of Paris
8 Papers
Vincent Jonchère is an academic researcher from University of Paris. The author has contributed to research in topics: Microsatellite instability & Cancer. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of Vincent Jonchère include French Institute of Health and Medical Research.
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Papers
Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas
Renato Micelli Lupinacci,Renato Micelli Lupinacci,Anastasia R. Goloudina,Olivier Buhard,Jean-Baptiste Bachet,Raphaël Maréchal,Pieter Demetter,Jérôme Cros,Armelle Bardier-Dupas,Ada Collura,Ada Collura,Pascale Cervera,Pascale Cervera,Aurelie Scriva,Sylvie Dumont,Pascal Hammel,Alain Sauvanet,Christophe Louvet,Jean-Robert Delpero,François Paye,Jean-Christophe Vaillant,Thierry André,Jean Closset,Jean-François Emile,Jean-Luc Van Laethem,Vincent Jonchère,Issam Abd Alsamad,Martine Antoine,Anita Rodenas,Jean-François Fléjou,Jean-François Fléjou,Nelson Dusetti,Juan L. Iovanna,Alex Duval,Alex Duval,Magali Svrcek,Magali Svrcek +36 more
TL;DR: Examining immunohistochemical analyses of PDAC specimens identified those with dMMR, based on loss of mismatch repair proteins MLH1, MSH2, MSh6, and/or PMS2 as well as potentially immunogenic mutations because of MSI in coding repeat sequences, which did not differ significantly between patients with PDACs with d MMR or MSI vs without.
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Performance of Next-Generation Sequencing for the Detection of Microsatellite Instability in Colorectal Cancer With Deficient DNA Mismatch Repair.
Toky Ratovomanana,Romain Cohen,Magali Svrcek,Florence Renaud,Florence Renaud,Pascale Cervera,Aurélie Siret,Quentin Letourneur,Olivier Buhard,Pierre Bourgoin,Erell Guillerm,Coralie Dorard,Rémy Nicolle,Mira Ayadi,Mehdi Touat,Franck Bielle,Marc Sanson,Philippe Le Rouzic,Marie-Pierre Buisine,Guillaume Piessen,Guillaume Piessen,Ada Collura,Jean-François Fléjou,Aurélien de Reyniès,Florence Coulet,François Ghiringhelli,Thierry André,Vincent Jonchère,Alex Duval +28 more
TL;DR: In this article, a new NGS-based algorithm, MSICare, was proposed to detect microsatellite instability arising from defective mismatch repair (dMMR) in patients with metastatic colorectal cancer (mCRC) before treatment with immune checkpoint inhibitors (ICI).
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Adrenal gland as a sanctuary site for immunotherapy in patients with microsatellite instability-high metastatic colorectal cancer.
Romain Cohen,Vincent Jonchère,Christelle De La Fouchardiere,Toky Ratovomanana,Quentin Letourneur,Mira Ayadi,Lucile Armenoult,Adrien Buisson,Matthieu Sarabi,Anna Pellat,Raphael Colle,François Paye,Pierre Meeus,Magali Svrcek,Alex Duval,Thierry André +15 more
TL;DR: In this article, a case series describes five patients with ICI-treated metastatic colorectal cancers (mCRC) harboring microsatellite instability (MSI) with disease progression limited to the adrenal glands.
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Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability.
Vincent Jonchère,Laetitia Marisa,Malorie Greene,Alain Virouleau,Alain Virouleau,Olivier Buhard,Romane Bertrand,Magali Svrcek,Pascale Cervera,Anastasia R. Goloudina,Erell Guillerm,Florence Coulet,Samuel Landman,Toky Ratovomanana,Sylvie Job,Mira Ayadi,Nabila Elarouci,Lucile Armenoult,Fatiha Merabtene,Sylvie Dumont,Yann Parc,Jérémie H. Lefevre,Thierry André,Jean-François Fléjou,Agathe Guilloux,Ada Collura,Aurélien de Reyniès,Alex Duval +27 more
TL;DR: The present results identify the positive and negative driver somatic mutations acting in MSI-driven tumorigenesis, suggesting that genomic instability in MSI CRC plays a dual role in achieving tumor cell transformation.
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Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability Positive Selection Pressure Mutational Background Negative Selection Pressure Mutational Frequency Microsatellite length (bp)
Vincent Jonchère,Laetitia Marisa,Malorie Greene,Alain Virouleau,Olivier Buhard,Romane Bertrand,Magali Svrcek,Pascale Cervera,Anastasia R. Goloudina,Erell Guillerm,Florence Coulet,Samuel Landman,Toky Ratovomanana,Sylvie Job,Mira Ayadi,Nabila Elarouci,Lucile Armenoult,Fatiha Merabtene,Sylvie Dumont,Y. Parc,Jérémie H. Lefevre,Thierry André,Jean-François Fléjou,Agathe Guilloux,Ada Collura,Aurélien de Reyniès,Alex Duval +26 more
- 01 Jan 2018
TL;DR: The present results identify the positive and negative driver somatic mutations acting in MSI-driven tumorigenesis, suggesting that genomic instability in MSI CRC plays a dual role in achieving tumor cell transformation.
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