Vincent G. DeMarco
University of Missouri
137 Papers
1K Citations
Vincent G. DeMarco is an academic researcher from University of Missouri. The author has contributed to research in topics: Insulin resistance & Medicine. The author has an hindex of 42, co-authored 128 publications. Previous affiliations of Vincent G. DeMarco include University of Alabama at Birmingham & Veterans Health Administration.
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Papers
Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice.
Scott Brown,Cassandra Smith,Alex Meuth,Maloree Khan,Annayya R. Aroor,Hannah M Cleeton,Gerald A. Meininger,James R. Sowers,Vincent G. DeMarco,Bysani Chandrasekar,Ravi Nistala,Shawn B. Bender +11 more
TL;DR: It is demonstrated that DPP‐4 inhibition with Saxa prevents Ang II‐induced cardiac diastolic dysfunction, fibrosis, and inflammation associated with unique shifts in CD11c‐expressing leukocytes and CD8+ lymphocytes.
DPP4 inhibition attenuates filtration barrier injury and oxidant stress in the zucker obese rat.
Ravi Nistala,Javad Habibi,Annayya R. Aroor,James R. Sowers,Melvin R. Hayden,Alex Meuth,William C Knight,Tamara S. Hancock,Thomas Klein,Vincent G. DeMarco,Adam Whaley-Connell +10 more
TL;DR: Obesity‐related glomerulopathy is characterized initially by glomerular hyperfiltration with hypertrophy and then development of proteinuria and there has been recent interest in targeting dipeptidyl peptidase 4 (DPP4) enzyme due to increasing role in non‐enzymatic cellular processes.
Endothelial Estrogen Receptor-α Does Not Protect Against Vascular Stiffness Induced by Western Diet in Female Mice.
Camila Manrique,Guido Lastra,Francisco I. Ramirez-Perez,Dominic Haertling,Vincent G. DeMarco,Annayya R. Aroor,Guanghong Jia,Dongqing Chen,Brady J. Barron,Mona Garro,Jaume Padilla,Luis A. Martinez-Lemus,James R. Sowers +12 more
TL;DR: Interestingly, ablation of ERα in ECs reduced WD-induced vascular stiffness and improved endothelial-dependent dilation, suggesting that in the setting of a WD, endothelial ERα signaling contributes to vascular stiffening in females.
Attenuation of NADPH Oxidase Activation and Glomerular Filtration Barrier Remodeling With Statin Treatment
Adam Whaley-Connell,Javad Habibi,Ravi Nistala,Shawna A. Cooper,Poorna R. Karuparthi,Melvin R. Hayden,Nathan Rehmer,Vincent G. DeMarco,Bradley T. Andresen,Yongzhong Wei,Carlos M. Ferrario,James R. Sowers +11 more
TL;DR: A role is supported for increased NADPH oxidase activity and subunit expression with resultant reactive oxygen species formation in the kidney and podocyte and statin attenuation seems to play roles in the abrogation of oxidative stress-induced filtration barrier injury and consequent albuminuria.
Nebivolol Attenuates Redox-Sensitive Glomerular and Tubular Mediated Proteinuria in Obese Rats
Javad Habibi,Melvin R. Hayden,James R. Sowers,Lakshmi Pulakat,Roger D. Tilmon,Camila Manrique,Guido Lastra,Vincent G. DeMarco,Adam Whaley-Connell,Adam Whaley-Connell +9 more
TL;DR: The results of this study suggest the beneficial effect of nebivolol on proteinuria was derived from improvements in weight and insulin sensitivity and reductions in renal oxidative stress in a state of obesity and insulin resistance.