Vikram Narayan
University of Edinburgh
19 Papers
118 Citations
Vikram Narayan is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Protein structure & Ubiquitin ligase. The author has an hindex of 12, co-authored 19 publications. Previous affiliations of Vikram Narayan include Edinburgh Cancer Research Centre & University of California, San Francisco.
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Papers
Docking-dependent Ubiquitination of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by the
Vikram Narayan,Emmanuelle Pion,Vivien Landre,Kathryn L. Ball +3 more
- 01 Jan 2011
TL;DR: In this paper, the C terminus of Hsc70-interacting protein (CHIP) was shown to chaperone IRF-1 in unstressed cells, and this site is sufficient to form a stable complex with CHIP.
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A Multiprotein Binding Interface in an Intrinsically Disordered Region of the Tumor Suppressor Protein Interferon Regulatory Factor-1
Vikram Narayan,Petr Halada,Lenka Hernychová,Yuh Ping Chong,Jitka Žáková,Ted R. Hupp,Borivoj Vojtesek,Kathryn L. Ball +7 more
TL;DR: The use of peptide aptamer-based affinity chromatography coupled with mass spectrometry to define a multiprotein binding interface on IRF-1 (Mf2 domain; amino acids 106–140) and to identify Mf2-binding proteins from A375 cells are described.
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Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation
TL;DR: A role for discrete motifs in the enhancer domain of IRF-1 in directing polyubiquitination and degradation is established and support is given to the idea that the degradation of selective substrates can be regulated at multiple steps in the ubiquitin-proteasome system.
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Probing Pedomorphy and Prolonged Lifespan in Naked Mole-Rats and Dwarf Mice.
Rochelle Buffenstein,Kaitlyn N. Lewis,Patrick A. Gibney,Vikram Narayan,Kelly M. Grimes,Megan Smith,Tzuhua D Lin,Holly M. Brown-Borg +7 more
TL;DR: Pedomorphy, maintenance of juvenile traits throughout life, is most pronounced in extraordinarily long-lived naked mole-rats, and the nature of these intrinsic pedomorphic features may also contribute to their prolonged youthfulness, longevity, and healthspan.
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Exploiting the MDM2-CK1α Protein-Protein Interface to Develop Novel Biologics That Induce UBL-Kinase-Modification and Inhibit Cell Growth
TL;DR: This approach provides a technological blueprint, complementing siRNA and chemical biology approaches, by exploiting protein-protein interactions in order to develop Biologics to manipulate novel types of signalling pathways such as cross-talk between NEDDylation, protein kinase signalling, and cell survival.