9 Papers
18 Citations
Vicky Mody is an academic researcher from Philadelphia College of Osteopathic Medicine. The author has contributed to research in topics: Protease & Medicine. The author has an hindex of 2, co-authored 4 publications.
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Papers
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents.
Vicky Mody,Joanna Ho,Savannah Wills,Ahmed Mawri,Latasha Lawson,Maximilian C. C. J. C. Ebert,Guillaume M Fortin,Srujana Rayalam,Shashidharamurthy Taval +8 more
- 20 Jan 2021
TL;DR: In this paper, the authors identified potential drugs that target the 3-chymotrypsin like protease (3CLpro), the main protease that is pivotal for the replication of SARS-CoV-2.
Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro
Devin S. M. Lewis,Joanna Ho,Savannah Wills,Anasha Kawall,Avini Sharma,Krishna Chavada,Maximilian C. C. J. C. Ebert,Stefania Evoli,Ajay Singh,Srujana Rayalam,Vicky Mody,Shashidharamurthy Taval +11 more
TL;DR: In this article , in vitro enzymatic inhibitory activity of active ingredients in the oral mouth rinse products: aloin A and B, chlorhexidine, eucalyptol, hexetidine, menthol, triclosan, methyl salicylate, sodium fluoride and povidone, against two important proteases of SARS-CoV-2 PLpro and 3CLpro was assessed.
Antiviral drugs
Essie Samuel,Krysten A. McNaught,Jessica L. Mulbah,Hazhir HajiAlilou,Vicky Mody,Drew W Cates +5 more
TL;DR: In this article , the authors reviewed side effects reported with the use of antivirals for the treatment of the following infections: coronavirus disease 2019 (COVID-19), cytomegalovirus (CMV), hepatitis B virus (HBV) and hepatitis C Virus (HCV), herpes simplex viruses 1 and 2 (HSV-1, -2), human immunodeficiency virus (HIV), and influenza virus.
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Synthesis, Pharmacokinetics, and Toxicity of Nano-Drug Carriers
Noah Tedla,Jose Ruiz,Vicky Mody,Xinyu Wang,Vishakha Bhave +4 more
- 01 Jan 2021
TL;DR: In this article, the synthesis of clinically important metallic and nonmetallic nano-drug carriers and the process to alter their physicochemical properties for their application in therapy and/or diagnosis are discussed.
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Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity
Anasha Kawall,Devin S. M. Lewis,Avini Sharma,Krishna Chavada,Rahul Deshmukh,Srujana Rayalam,Vicky Mody,Shashidharamurthy Taval +7 more
TL;DR: In this paper , the inhibitory effects of phytochemicals on the SARS-CoV-2 PLpro enzyme were investigated and it was shown that phytochemical compounds such as catechin, epigallocatechin gallate (EGCG), mangiferin, myricetin, rutin, and theaflavin exhibited inhibitory activity with IC50 values of 14.2, 128.4, 95.3, 12.5, 61.7, 104.7 and 13.2 μM, respectively.
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