Vesela Encheva
Francis Crick Institute
40 Papers
181 Citations
Vesela Encheva is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Biology & Proteome. The author has an hindex of 20, co-authored 38 publications. Previous affiliations of Vesela Encheva include Health Protection Agency & Imperial College London.
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Papers
Naive pluripotency is associated with global DNA hypomethylation
Harry G. Leitch,Kirsten R. McEwen,Aleksandra Turp,Vesela Encheva,Thomas L. Carroll,Nils Grabole,Nils Grabole,William Mansfield,Buhe Nashun,Jaysen G Knezovich,Austin Smith,M. Azim Surani,M. Azim Surani,Petra Hajkova +13 more
TL;DR: It is established that culture in 2i instills a naive pluripotent state with a distinctive epigenetic configuration that parallels molecular features observed in both the preimplantation epiblast and nascent PGCs.
De novo DNA methylation drives 5hmC accumulation in mouse zygotes
Rachel Amouroux,Buhe Nashun,Kenjiro Shirane,Shoma Nakagawa,Peter W. S. Hill,Zelpha D’Souza,Manabu Nakayama,Masashi Matsuda,Aleksandra Turp,Elodie Ndjetehe,Vesela Encheva,Nobuaki Kudo,Haruhiko Koseki,Hiroyuki Sasaki,Petra Hajkova +14 more
TL;DR: It is demonstrated using detailed immunofluorescence analysis and ultrasensitive LC-MS-based quantitative measurements that the initial loss of paternal 5mC does not require 5hmC formation, and an intricate interplay between DNA demethylation, de novo methylation and Tet3-driven hydroxylation is revealed.
Multiomic Analysis of the UV-Induced DNA Damage Response.
Stefan Boeing,Laura Williamson,Vesela Encheva,Ilaria Gori,Rebecca E. Saunders,Rachael Instrell,Ozan Aygün,Marta Rodríguez-Martínez,Juston C. Weems,Gavin Kelly,Joan W. Conaway,Joan W. Conaway,Ronald C. Conaway,Ronald C. Conaway,Aengus Stewart,Michael Howell,Ambrosius P. Snijders,Jesper Q. Svejstrup +17 more
TL;DR: A role for the poorly studied, melanoma-associated serine/threonine kinase 19 (STK19) is uncovered, which provides a systems-wide overview of the diverse cellular processes connected to the transcription-related DNA damage response.
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Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway
Valentina Rapisarda,Michela Borghesan,Veronica Miguela,Vesela Encheva,Ambrosius P. Snijders,Amaia Lujambio,Ana O'Loghlen +6 more
TL;DR: The data show that integrin β3 subunit is a marker and regulator of senescence and shows an increase in β3 levels in a subset of tissues during aging.
167
Regulation of the RNAPII Pool Is Integral to the DNA Damage Response.
Ana Tufegdžić Vidaković,Richard Mitter,Gavin Kelly,Michelle Neumann,Michelle Harreman,Marta Rodríguez-Martínez,Anna Herlihy,Juston C. Weems,Stefan Boeing,Vesela Encheva,Liam Gaul,Laura Milligan,David Tollervey,Ronald C. Conaway,Ronald C. Conaway,Joan W. Conaway,Joan W. Conaway,Ambrosius P. Snijders,Aengus Stewart,Jesper Q. Svejstrup +19 more
TL;DR: In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II (RNAPII), and genome-wide transcription shutdown, provided by the finding that ubiquitylation of RNAPII itself, at a single lysine (RPB1 K1268), is the focal point for DNA-damage-response coordination.
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