Veronica Saenz-Vash
Novartis
5 Papers
6 Citations
Veronica Saenz-Vash is an academic researcher from Novartis. The author has contributed to research in topics: Myocilin & Epigenetics. The author has an hindex of 3, co-authored 5 publications.
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Papers
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
Gregory R. Hoffman,Rami Rahal,Frank Buxton,Kay Xiang,Gregory McAllister,Elizabeth Frias,Linda Bagdasarian,Janina Huber,Alicia Lindeman,Dongshu Chen,Rodrigo Romero,Nadire Ramadan,Tanushree Phadke,Kristy Haas,Mariela Jaskelioff,Boris G. Wilson,Matthew J. Meyer,Veronica Saenz-Vash,Huili Zhai,Vic E. Myer,Jeffery A. Porter,Nicholas Keen,Margaret E. McLaughlin,Craig Mickanin,Charles W. M. Roberts,Frank Stegmeier,Zainab Jagani +26 more
TL;DR: This study provides important mechanistic insight into the BRM/BRG1 synthetic lethal relationship, shows this finding translates in vivo, and highlights BRM as a promising therapeutic target for the treatment BRG1-mutant cancers.
395
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells
Jeffrey M. Lynch,Bing Li,Parvaneh Katoli,Chuanxi Xiang,Barrett Leehy,Nalini Rangaswamy,Veronica Saenz-Vash,Y. Karen Wang,Hong Lei,Thomas B. Nicholson,Erik Meredith,Dennis S Rice,Ganesh Prasanna,Amy Chen +13 more
TL;DR: A model by which mutant MYOC causes glaucoma is proposed, and it is proposed that therapeutic treatment of patients having a MYOC mutation may focus on disrupting the MYOC–CRYAB complexes.
19
Full-length myocilin protein is purified from mammalian cells as a dimer.
Parvaneh Katoli,Adarsh Godbole,Michael J. Romanowski,Kirk Clark,Erik Meredith,Veronica Saenz-Vash,Y. Karen Wang,Nancy Lewicki,Andrew Anh Nguyen,Jeffrey M. Lynch +9 more
TL;DR: Two methods by which to isolate sufficient quantities of human full-length MYOC protein from mammalian cells are described and a structure for the MYOC dimer is proposed.
6
Patent
Markers for isocitrate dehydrogenase inhibitors
Young Shin Cho,Julian Levell,Fallon Lin,Margaret E. McLaughlin,Ronald Meyer,Raymond Pagliarini,Veronica Saenz-Vash,Olga Shebanova,Huili Zhai +8 more
- 24 Feb 2014
TL;DR: In this article, the authors presented methods of detecting cancer and detecting activity of IDH inhibitors, and methods of screening for IDH inhibitor by detecting levels of H3K9me2.
2
Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA
Unmesh Jadhav,Unmesh Jadhav,Alessia Cavazza,Alessia Cavazza,Kushal K. Banerjee,Kushal K. Banerjee,Huafeng Xie,Nicholas K. O’Neill,Veronica Saenz-Vash,Zachary T. Herbert,Shariq Madha,Stuart H. Orkin,Huili Zhai,Ramesh A. Shivdasani +13 more
TL;DR: In adult mouse cells, hypomethylated CpG dinucleotides preserve a nearly complete archive of tissue-specific developmental enhancers, stably marking decommissioned sites and enabling recovery of this epigenetic memory.