Veronica Iannucci
Ghent University
7 Papers
1 Citations
Veronica Iannucci is an academic researcher from Ghent University. The author has contributed to research in topics: Gene & Innate immune system. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Veronica Iannucci include Ghent University Hospital & Icahn School of Medicine at Mount Sinai.
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Papers
Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation
Alessia Landi,Jolien Vermeire,Veronica Iannucci,Veronica Iannucci,Hanne Vanderstraeten,Evelien Naessens,Mostafa Bentahir,Mostafa Bentahir,Bruno Verhasselt +8 more
TL;DR: Insight is given in the HIV-1-mediated CD4 down-regulation at the level of the plasma membrane and early endosomes and four possible new HIV- 1 replication co-factors are identified.
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HIV-1 infection induces a type I IFN response in primary CD4+ T cells
Jolien Vermeire,Veronica Iannucci,Evelien Naessens,Kathleen Van Landeghem,Hanne Vanderstraeten,Jo Van Damme,Bruno Verhasselt +6 more
TL;DR: Activated PBLs are shown to be capable of producing relevant levels of type 1 IFN in response to HIV-1 infection and recognition of newly expressed HIV RNA or proteins as a main trigger of the innate response in these cells is suggested.
Rho GTPase Cdc42 is essential for human T-cell development.
Kaatje Smits,Veronica Iannucci,Veronique Stove,Peter Van Hauwe,Evelien Naessens,Pieter Meuwissen,Kevin K. Ariën,Mostafa Bentahir,Jean Plum,Bruno Verhasselt +9 more
TL;DR: This is the first report on Rho GTPases in human T-cell development, showing the essential role of Cdc42 and suggesting that enhanced apoptotic death and reduced proliferation rather than disturbed migration explains the decreased thymopoiesis induced by dominant negative CDC42.
Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
Pieter Meuwissen,Bettina Stolp,Veronica Iannucci,Jolien Vermeire,Evelien Naessens,Kalle Saksela,Matthias Geyer,Guido Vanham,Kevin K. Ariën,Kevin K. Ariën,Oliver T. Fackler,Bruno Verhasselt +11 more
TL;DR: It is proposed that this highly conserved three amino acid VGF motif together with the acidic cluster and the proline-rich motif form a previously unrecognized amphipathic surface on Nef and thus represents a prime target for the pharmacological inhibition of Nef.
One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.
TL;DR: An extensive review of the knowledge gained so far on the modulation of expression of HIV-1, HIV-2 and SIV Nef protein is provided.