Veronica Bergan
Norwegian College of Fishery Science
12 Papers
249 Citations
Veronica Bergan is an academic researcher from Norwegian College of Fishery Science. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 7, co-authored 10 publications.
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Papers
Atlantic salmon interferon genes: cloning, sequence analysis, expression, and biological activity.
TL;DR: Human embryonic kidney 293 cells transfected with the SasaIFN-alpha1 cDNA gene produced high titers of acid-stable antiviral activity, which protected salmonid cells against infectious pancreatic necrosis virus (IPNV) and also induced Mx protein in the cells.
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Regulation and function of interferon regulatory factors of Atlantic salmon.
TL;DR: The findings suggest that AsIRF3 is the main regulator of salmon IFNa1 production along with As IRF1, which is less potent, which confirms a similar role for salmon IRF3 as mammalian IRF 3 to be one of the main IRFs eliciting salmon IF Na1 production.
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Atlantic salmon IPS-1 mediates induction of IFNa1 and activation of NF-κB and localizes to mitochondria.
TL;DR: This work shows that an Atlantic salmon homologue of IPS-1 (AsIPS-1) mediates activation of the salmon IFNa1 promoter and an NF-kappaB driven promoter, and plays a key role in the induction of Atlantic salmon IF Na1, which appears to be the first and major IFN induced in host cells upon recognition of viral dsRNA.
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Promoters of type I interferon genes from Atlantic salmon contain two main regulatory regions.
TL;DR: The established IFN promoter‐luciferase assay will be useful in studies of host–virus interactions in Atlantic salmon, as many viruses are known to encode proteins that prevent IFN synthesis by inhibition of promoter activation.
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The Atlantic salmon Z-DNA binding protein kinase phosphorylates translation initiation factor 2 alpha and constitutes a unique orthologue to the mammalian dsRNA-activated protein kinase R.
TL;DR: A role for PKZ, like PKR, in host defense against virus infection is supported, and it is shown that wild‐type Atlantic salmon PKZ has a direct inhibitory effect on protein synthesis after transient expression in Chinook salmon embryo cells.
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