Verena Schultz

TL;DR: It is demonstrated that miRNA regulation in marmoset (Callithrix jacchus) and C57/BL6 mouse EAE lesions largely resembles mi RNA regulation in active human MS lesions.

TL;DR: In this article , the authors performed single infections and coinfections with SARS-CoV-2 combined with IAV or RSV in cultures of human bronchial epithelial cells and combined microscopy with quantification of viral replication in the presence or absence of an innate immune inhibitor to determine changes in virus-induced pathology, virus spread, and virus replication.

TL;DR: Testing the hypothesis that ZIKV-associated degeneration of neuronal processes is dependent on activation of Sterile alpha and armadillo motif-containing protein 1 (SARM1), an NADase that acts as a central executioner in a conserved axon degeneration pathway identifies a role for SARM1 in the pathogenesis of ZikV infection, which may reflect Sarm1's conserved prodegenerative function, independent of its NADase activity.

TL;DR: It is demonstrated that a subset of lipid-reactive human and murine IgMs induce a functional anti-viral response that inhibits replication of encephalitic Alpha and Orthobunyaviruses in multi-cellular central nervous system cultures.