Veena Gopalakrishnan
National University of Singapore
10 Papers
3 Citations
Veena Gopalakrishnan is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cancer & Telomere. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Veena Gopalakrishnan include Okayama University.
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Papers
Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer
Chia Huey Ooi,Tatiana Ivanova,Jeanie Wu,Minghui Lee,Iain Beehuat Tan,Jiong Tao,Lindsay C. Ward,Jun Hao Koo,Veena Gopalakrishnan,Yansong Zhu,Lai Ling Cheng,Julian Lee,Sun Young Rha,Hyun Cheol Chung,Kumaresan Ganesan,Jimmy Bok Yan So,Khee Chee Soo,Dennis T. H. Lim,Weng Hoong Chan,Wai-Keong Wong,David D.L. Bowtell,Khay Guan Yeoh,Heike Grabsch,Alex Boussioutas,Alex Boussioutas,Patrick Tan +25 more
TL;DR: Using gene expression signatures, this paper identified major oncogenic pathways in gastric cancer (GC) with significant relationships to patient survival, and devised an in-silico strategy to map patterns of pathway activation in 301 primary gastric cancers, the second highest cause of global cancer mortality.
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Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer
Chia Huey Ooi,Tatiana Ivanova,Jeanie Wu,Minghui Lee,Iain Beehuat Tan,Jiong Tao,Lindsay C. Ward,Jun Hao Koo,Veena Gopalakrishnan,Yansong Zhu,Lai Ling Cheng,Julian Lee,Sun Young Rha,Hyun Cheol Chung,Kumaresan Ganesan,Jimmy Bok Yan So,Khee Chee Soo,Dennis T. H. Lim,Weng Hoong Chan,Wai-Keong Wong,David D.L. Bowtell,Khay Guan Yeoh,Heike Grabsch,Alex Boussioutas,Alex Boussioutas,Patrick Tan +25 more
- 01 Oct 2009
TL;DR: Using gene expression signatures, an in silico strategy to map patterns of oncogenic pathway activation in 301 primary gastric cancers showed reproducible and significant survival differences in multiple cohorts, suggesting that pathway interactions may play an important role in influencing disease behavior.
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Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer
Hermioni Zouridis,Niantao Deng,Tatiana Ivanova,Yansong Zhu,Bernice Wong,Dan Huang,Yonghui Wu,Yingting Wu,Iain Beehuat Tan,Natalia Liem,Veena Gopalakrishnan,Qin Luo,Jeanie Wu,Minghui Lee,Wei Peng Yong,Liang Kee Goh,Bin Tean Teh,Bin Tean Teh,Steve Rozen,Steve Rozen,Patrick Tan +20 more
TL;DR: The authors extensively characterized methylation patterns in human gastric cancers, which revealed tumor-specific arrangements of hyper- and hypomethylation and long-range regions of epigenetic silencing (LRESs) in CIMP tumors.
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Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer
Tatiana Ivanova,Hermioni Zouridis,Yonghui Wu,Lai Ling Cheng,Iain Beehuat Tan,Veena Gopalakrishnan,Chia Huey Ooi,Julian Lee,Luo Qin,Jeanie Wu,Minghui Lee,Sun Young Rha,Dan Huang,Natalia Liem,Khay Guan Yeoh,Wei Peng Yong,Bin Tean Teh,Patrick Tan,Patrick Tan +18 more
TL;DR: Epigenomic analysis identified bone morphogenetic protein 4 (BMP4) as an epigenetically regulated gene highly expressed in cisplatin-resistant lines, and functional assays confirmed that BMP4 is necessary and sufficient for the expression of several prooncogenic traits, likely mediated through stimulation of the epithelial-mesenchymal transition.
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