Vasyl Eisenberg
Bar-Ilan University
4 Papers
39 Citations
Vasyl Eisenberg is an academic researcher from Bar-Ilan University. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 4, co-authored 4 publications.
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Papers
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.
Francesca Alfei,Kristiyan Kanev,Maike Hofmann,Ming Wu,Hazem E. Ghoneim,Hazem E. Ghoneim,Patrick Roelli,Patrick Roelli,Patrick Roelli,Daniel T. Utzschneider,Madlaina von Hoesslin,Jolie G. Cullen,Yiping Fan,Vasyl Eisenberg,Dirk Wohlleber,Katja Steiger,Doron Merkler,Mauro Delorenzi,Mauro Delorenzi,Percy A. Knolle,Cyrille J. Cohen,Robert Thimme,Benjamin Youngblood,Dietmar Zehn +23 more
TL;DR: It is shown that TOX is a critical factor for the normal progression of T cell dysfunction and the maintenance of exhausted T cells during chronic infection, and provide a link between the suppression of effector function intrinsic to CD8 T cells and protection against immunopathology.
720
Targeting Multiple Tumors Using T-Cells Engineered to Express a Natural Cytotoxicity Receptor 2-Based Chimeric Receptor.
Vasyl Eisenberg,Katerina Shamalov,Shimrit Meir,Shiran Hoogi,Rhitajit Sarkar,Rhitajit Sarkar,Shirel Pinker,Gal Markel,Angel Porgador,Cyrille J. Cohen +9 more
TL;DR: The results show that expression in primary lymphocytes of an NCR2-derived CAR confers T-cells with the ability to specifically recognize heterogeneous tumors and to mediate tumor cytotoxicity in a mouse model.
23
T-cells "à la CAR-T(e)" - Genetically engineering T-cell response against cancer.
TL;DR: An overview of the most recent developments in the field of T-cell genetic engineering including TCR-gene transfer and CAR T-cells strategies is given and the development of other types of genetic modifications to enhance their anti-tumor immune response is elaborate.
23
A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function.
TL;DR: It is proposed that TIGIT-based CSR can substantially enhance T-cell function and thus contribute to the improvement of engineered T cell-based immunotherapy.