Vanessa Tan
Macquarie University
23 Papers
17 Citations
Vanessa Tan is an academic researcher from Macquarie University. The author has contributed to research in topics: Kynurenine pathway & Kynurenine. The author has an hindex of 7, co-authored 19 publications.
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Papers
Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression.
Chai K. Lim,Chai K. Lim,Ayse Bilgin,David B. Lovejoy,Vanessa Tan,Sonia Bustamante,Bruce V. Taylor,Alban Bessede,Bruce J. Brew,Gilles J. Guillemin +9 more
TL;DR: It is suggested that abnormalities in the KP may be associated with the switch from early-mild stage MS to debilitating progressive forms of MS and that analysis of KP metabolites in MS patient serum may have application as MS disease biomarkers.
Effects of Sleep Deprivation on the Tryptophan Metabolism.
Abid Bhat,Abid Bhat,Ananda Staats Pires,Vanessa Tan,Saravana Babu Chidambaram,Gilles J. Guillemin +5 more
- 23 Nov 2020
TL;DR: The impact of sleep deprivation on tryptophan metabolism and associated complication in the brain is linked to increased production and accumulation of kynurenic acid in various regions of the brain.
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Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis
Jong Min Lee,Vanessa Tan,David B. Lovejoy,Nady Braidy,Dominic B. Rowe,Bruce J. Brew,Gilles J. Guillemin +6 more
TL;DR: A review highlights the potential roles of QUIN in ALS, and explores KP modulation as a therapeutic candidate in ALS.
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Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression.
Benjamin Heng,Ayse Bilgin,David B. Lovejoy,Vanessa Tan,Heloisa Helena Milioli,Laurence Gluch,Sonia Bustamante,Tharani Sabaretnam,Pablo Moscato,Chai K. Lim,Gilles J. Guillemin +10 more
TL;DR: Gene, protein expression, and KP metabolomic profiling have shown that the downstream KP enzymes KMO and KYNU are highly upregulated in the HER2-enriched and TN BrCa subtypes, leading to increased production of the potent immunosuppressive metabolites anthranilic acid (AA) and 3-hydroxylanthranilic Acid (3HAA).
Sodium Butyrate and Indole-3-propionic Acid Prevent the Increase of Cytokines and Kynurenine Levels in LPS-induced Human Primary Astrocytes.
Michelle L. Garcez,Michelle L. Garcez,Vanessa Tan,Benjamin Heng,Gilles J. Guillemin +4 more
- 28 Dec 2020
TL;DR: The crosstalk between central nervous system (CNS) and gut microbiota plays key roles in neuroinflammation and chronic immune activation that are common features of all neurodegenerative diseases as discussed by the authors.
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