Vanessa Brys
Katholieke Universiteit Leuven
5 Papers
Vanessa Brys is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Membrane protein & Peroxin. The author has an hindex of 5, co-authored 5 publications.
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Papers
Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency.
P. P. Van Veldhoven,Els Meyhi,R. H. Squires,Marc Fransen,B. Fournier,Vanessa Brys,M. J. Bennett,Guy P. Mannaerts +7 more
TL;DR: In this article, the 2R-isomer of 2-methylacyl-CoA (2-Methylacyl CoA) racemase was evaluated in a young girl, presenting with elevated urinary levels of trihydroxycholestanoic acid metabolites but normal plasma levels of very long chain fatty acids.
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Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1).
TL;DR: To allow for the diagnosis of human disorders that might be linked to a deficient lyase, the human sphingosine-1-phosphate lyase cDNA was cloned and the gene was mapped to chromosome 10q22 by fluorescent in situ hybridization.
High Accuracy Mutation Detection in Leukemia on a Selected Panel of Cancer Genes
Zeynep Kalender Atak,Kim De Keersmaecker,Valentina Gianfelici,Ellen Geerdens,Roel Vandepoel,Daphnie Pauwels,Michaël Porcu,Idoya Lahortiga,Vanessa Brys,Willy G. Dirks,Hilmar Quentmeier,Jacqueline Cloos,Harry Cuppens,Anne Uyttebroeck,Peter Vandenberghe,Jan Cools,Stein Aerts +16 more
TL;DR: An optimized analysis pipeline for Roche/454 data is established that can be applied to accurately detect gene mutations in cancer, which led to the identification of several new candidate T-ALL driver mutations.
Analysis of Human Pex19p's Domain Structure by Pentapeptide Scanning Mutagenesis
TL;DR: The observation that Pex19p contains two distinct binding sites for Pex3p suggests that the peroxin may bind PMPs in multiple places and for multiple purposes.
Potential Role for Pex19p in Assembly of PTS-Receptor Docking Complexes
TL;DR: It is demonstrated that a mutant of Pex13p that fails to bind to Pex19p nevertheless targets to and integrates into the peroxisomal membrane, supporting a role for this peroxin in regulating assembly/disassembly of membrane-associated protein complexes.