Valerie B. O'Donnell
Cardiff University
177 Papers
1.1K Citations
Valerie B. O'Donnell is an academic researcher from Cardiff University. The author has contributed to research in topics: Chemistry & Inflammation. The author has an hindex of 53, co-authored 159 publications. Previous affiliations of Valerie B. O'Donnell include University of Bristol & University of Alabama at Birmingham.
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Papers
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?
Nils Helge Schebb,Hartmut Kühn,Astrid S. Kahnt,Katharina M. Rund,Valerie B. O'Donnell,Nicolas Flamand,Marc Peters-Golden,Per-Johan Jakobsson,Karsten H. Weylandt,Nadine Rohwer,Robert C. Murphy,Gerd Geisslinger,Garret A. FitzGerald,Julien Hanson,Claes Dahlgren,Mohamad Wessam Alnouri,Stefan Offermanns,Dieter Steinhilber +17 more
TL;DR: In this paper , the proposed biosynthetic pathways of SPM formation, the current knowledge on SPM receptors and their signaling cascades and the analytical methods used to quantify these pro-resolving mediators in the context of their instability and their low concentrations are evaluated.
Metabolic plasticity in resting and thrombin activated platelets.
Saranya Ravi,Balu K. Chacko,Hirotaka Sawada,Philip A. Kramer,Michelle S. Johnson,Gloria A. Benavides,Valerie B. O'Donnell,Marisa B. Marques,Victor M. Darley-Usmar +8 more
TL;DR: Both glycolysis and oxidative phosphorylation contribute to platelet metabolism in the resting and activated state, with fatty acid oxidation and to a smaller extent glutaminolysis contributing to the increased energy demand.
Nitration of unsaturated fatty acids by nitric oxide-derived reactive species
Valerie B. O'Donnell,Jason P. Eiserich,Allison Bloodsworth,Phillip Chumley,Marion Kirk,Stephen Barnes,Victor M. Darley-Usmar,Bruce A. Freeman +7 more
TL;DR: Comparison of HPLC retention times and m/z for lipid nitration products indicate that the mechanisms of nitrated product formation converge at several points, suggesting that in vivo, nitrated lipids (LNO2, LONO2) may also possess bioactivity, for example through eicosanoid receptor binding activity, or by acting as antagonists/competitive inhibitors of eICosanoids receptor-ligand interactions.
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Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease
Stefan Uderhardt,Jochen A. Ackermann,Tobias Fillep,Victoria Jayne Hammond,Johann Willeit,Peter Santer,Manuel Mayr,Markus Biburger,Meike Miller,Katie R. Zellner,Konstantin Stark,Alexander Zarbock,Jan Rossaint,Irene Schubert,Dirk Mielenz,Barbara Dietel,Dorette Raaz-Schrauder,Cihan Ay,Thomas Gremmel,Johannes Thaler,Christian Heim,Martin Herrmann,Peter William Collins,Gernot Schabbauer,Nigel Mackman,David Voehringer,Jerry L. Nadler,James J. Lee,Steffen Massberg,Manfred Rauh,Stefan Kiechl,Georg Schett,Valerie B. O'Donnell,Gerhard Krönke +33 more
TL;DR: It is shown that eosinophils contributed to intravascular thrombosis by exhibiting a strong endogenous thrombin-generation capacity that relied on the enzymatic generation and active provision of a procoagulant phospholipid surface enriched in 12/15-lipoxygenase–derived hydroxyeicosatetraenoic acid–phosphatidylethanolamines.
15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclase.
Valerie B. O'Donnell,Kenneth B. Taylor,Sampath Parthasarathy,Hartmut Kühn,Doris Koesling,Andreas Friebe,Allison Bloodsworth,Victor M. Darley-Usmar,Bruce A. Freeman +8 more
TL;DR: Analysis of purified soybean and rabbit reticulocyte 15-lipoxygenase (15-LOX) and PA317 cells transfected with human 15- LOX revealed a rapid rate of linoleate-dependent nitric oxide (⋅NO) uptake that coincided with reversible inhibition of product ((13S)-hydroperoxyoctadecadienoic acid, or (13S-HPODE) formation.
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