Valeria Soberon
Technische Universität München
5 Papers
3 Citations
Valeria Soberon is an academic researcher from Technische Universität München. The author has contributed to research in topics: Plasma cell & Biology. The author has an hindex of 3, co-authored 5 publications. Previous affiliations of Valeria Soberon include Max Planck Society.
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Papers
GP130 activation induces myeloma and collaborates with MYC.
Tobias Dechow,Sabine Steidle,Katharina Götze,Martina Rudelius,Kerstin Behnke,Konstanze Pechloff,Susanne Kratzat,Lars Bullinger,Falko Fend,Valeria Soberon,Nadya Mitova,Zhoulei Li,Markus Thaler,Jan Bauer,Elke Pietschmann,Corinna Albers,Rebekka Grundler,Marc Schmidt-Supprian,Jürgen Ruland,Christian Peschel,Justus Duyster,Stefan Rose-John,Florian Bassermann,Ulrich Keller +23 more
TL;DR: It is demonstrated that ectopic expression of constitutively active GP130 (L-GP130) in a murine retroviral transduction-transplantation model induces rapid MM development of high penetrance and indicates that deregulated GP130 activity contributes to MM pathogenesis and that pathways downstream of GP 130 activity have potential as therapeutic targets in MM.
A20 and CYLD Do Not Share Significant Overlapping Functions during B Cell Development and Activation
Yuanyuan Chu,Valeria Soberon,Laura Glockner,Rudi Beyaert,Rudi Beyaert,Ramin Massoumi,Geert van Loo,Geert van Loo,Daniel Krappmann,Marc Schmidt-Supprian +9 more
TL;DR: It is demonstrated that A20 and CYLD do not share significant functions during B cell development and activation, and small but reproducible additive effects of the lack of A20 are observed in response to BCR cross-linking.
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autoimmunity in aged mice differentiation and hyperactivation and cause inflammation and B cells lacking the tumor suppressor TNFAIP3/A20 display impaired
Geert van Loo,Marc Schmidt-Supprian,Valeria Soberon,Dominik Schenten,Brigitte Mack,Miriam Reutelshöfer,Rudi Beyaert,Yuanyuan Chu,J. Christoph Vahl,Dilip Kumar,Klaus Heger,Arianna Bertossi,Edyta Wójtowicz +12 more
- 01 Jan 2011
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B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice
Yuanyuan Chu,J. Christoph Vahl,Dilip Kumar,Klaus Heger,Arianna Bertossi,Edyta Wójtowicz,Valeria Soberon,Dominik Schenten,Brigitte Mack,Miriam Reutelshöfer,Rudi Beyaert,Kerstin Amann,Geert van Loo,Marc Schmidt-Supprian +13 more
TL;DR: It is shown here that A20 is required for the normal differentiation of the marginal zone B and B1 cell subsets, and loss of A20 in B cells lowers their activation threshold and enhances proliferation and survival in a gene-dose-dependent fashion.
c-Rel gain in B cells drives germinal center reactions and autoantibody production
Maike Kober-Hasslacher,Hyunju Oh-Strauß,Dilip Kumar,Valeria Soberon,Carina Diehl,Maciej Lech,Thomas Engleitner,Eslam Katab,Vanesa Fernández-Sáiz,Guido Piontek,Hongwei Li,Björn H. Menze,Christoph Ziegenhain,Wolfgang Enard,Roland Rad,Jan P. Böttcher,Hans-Joachim Anders,Martina Rudelius,Marc Schmidt-Supprian +18 more
TL;DR: C-Rel expression in B cells of otherwise c-Rel-deficient mice fully rescued terminal B cell differentiation, underscoring its critical B cell-intrinsic roles and providing a link between c-rel gain and autoimmunity by showing that c- Rel overexpressing B cells caused autoantibody production and renal immune complex deposition.