Valer Jeso
Dartmouth College
12 Papers
11 Citations
Valer Jeso is an academic researcher from Dartmouth College. The author has contributed to research in topics: Ansamycin & Benzoquinone. The author has an hindex of 8, co-authored 12 publications. Previous affiliations of Valer Jeso include University of California, San Diego & Scripps Research Institute.
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Papers
Total synthesis of lehualide B by allylic alcohol-alkyne reductive cross-coupling.
Valer Jeso,Glenn C. Micalizio +1 more
TL;DR: The total synthesis of anticancer marine natural product lehualide B is described, which proceeds in just eight steps from a simple gamma-pyrone, does not require the use of protecting groups, and delivers each nonconjugated trisubstituted alkene with high levels of stereoselection.
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Synthesis and SAR of Lehualide B – A Marine-derived Natural Product with Potent Anti-Multiple Myeloma Activity
TL;DR: The synthesis and evaluation of a collection of lehualide-inspired analogues led to the elucidation of structure-activity relationships for this rare natural product that established important roles for the substituted γ-pyrone headgroup and the skipped polyene side chain.
Synthesis of Anhydroryanodol.
Kang Du,Matthew J. Kier,Zachary D. Stempel,Valer Jeso,Arnold L. Rheingold,Glenn C. Micalizio +5 more
TL;DR: The advances described demonstrate the value that programs in natural product total synthesis have in advancing organic chemistry, here through the design and realization of an annulation reaction that accom-plishes what previously established reactions do not.
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