Valentina Vaira
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
123 Papers
233 Citations
Valentina Vaira is an academic researcher from Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 32, co-authored 98 publications. Previous affiliations of Valentina Vaira include University of Massachusetts Medical School & Wistar Institute.
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Papers
Regulation of survivin expression by IGF-1/mTOR signaling.
TL;DR: In this article, the authors show that stimulation with insulin-like growth factor-1 (IGF-1) results in increased survivin expression in prostate cancer cells, independent of de novo gene transcription, changes in mRNA expression or modifications of survivin protein stability.
Imaging Metformin Efficacy as Add-On Therapy in Cells and Mouse Models of Human EGFR Glioblastoma.
Silvia Valtorta,Silvia Valtorta,Alessia Lo Dico,Isabella Raccagni,Isabella Raccagni,Cristina Martelli,Valentina Pieri,Paolo Rainone,Sergio Todde,Sergio Todde,Bastian Zinnhardt,Elisabetta De Bernardi,Angela Coliva,Letterio S. Politi,Thomas Viel,Andreas H. Jacobs,Rossella Galli,Luisa Ottobrini,Luisa Ottobrini,Valentina Vaira,Valentina Vaira,Rosa Maria Moresco,Rosa Maria Moresco +22 more
TL;DR: In this article, the authors evaluated the preclinical efficacy of Metformin (MET) as add-on therapy to Temozolomide (TMZ) and the ability of [18F]FLT (activity of thymidine kinase 1 related to cell proliferation) and [18 F]VC701 (translocator protein, TSPO) radiotracers to predict tumor response to therapy.
Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy
Jagadish C. Ghosh,Markus D. Siegelin,Valentina Vaira,Alice Faversani,Michele Tavecchio,Young Chan Chae,Sofia Lisanti,Paolo Rampini,Massimo Giroda,M. Cecilia Caino,Jae Ho Seo,Andrew V. Kossenkov,Ryan D. Michalek,David C. Schultz,Silvano Bosari,Lucia R. Languino,Dario C. Altieri +16 more
TL;DR: Novel combination therapies that target mitochondrial adaptation can dramatically improve on the efficacy of PI3K therapy in the clinic, and promote drug resistance by repurposing mitochondrial functions in bioenergetics and cell survival.
Inhaled CO2 vs. Hypercapnia Obtained by Low Tidal Volume or Instrumental Dead Space in Unilateral Pulmonary Artery Ligation: Any Difference for Lung Protection?
Elena Spinelli,Antonio Pesenti,G. Lopez,Anna Damia,F. Damarco,E. Garbelli,G. Dal Santo,Alessio Caccioppola,Giorgio Giudici,Virginia Figgiaconi,Osvaldo Biancolilli,M. Battistin,Caterina Lonati,Valentina Vaira,Lorenzo Rosso,Stefano Ferrero,Stefano Gatti,Tommaso Mauri +17 more
TL;DR: In a model of UPAL, inhaled CO2 but not hypercapnia grants bilateral lung protection, and mechanisms of protection include reduced overdistension of the non-ligated and increased perfusion of the ligated lung.
IMP3 expression in NSCLC brain metastases demonstrates its role as a prognostic factor in non-neuroendocrine phenotypes.
Alessandro Del Gobbo,Annamaria Morotti,Annamaria Morotti,Anna Eleonora Colombo,Valentina Vaira,Valentina Vaira,Giulia Ercoli,Chiara Pesenti,Chiara Pesenti,Eleonora Bonaparte,Elena Guerini-Rocco,Elena Guerini-Rocco,Andrea Di Cristofori,Marco Locatelli,Alessandro Palleschi,Stefano Ferrero,Stefano Ferrero +16 more
TL;DR: Results indicated that IMP3 is a strong prognostic factor in non-neuroendocrine brain metastases and in particular in patients with adenocarcinoma metastases.