Valentina Vaira
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
123 Papers
233 Citations
Valentina Vaira is an academic researcher from Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 32, co-authored 98 publications. Previous affiliations of Valentina Vaira include University of Massachusetts Medical School & Wistar Institute.
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Papers
Role of Strain Rate in the Pathogenesis of Ventilator-induced Lung Edema.
Alessandro Protti,Tommaso Maraffi,M. Milesi,Emiliano Votta,Alessandro Santini,P. Pugni,Davide T. Andreis,Francesco Nicosia,Emanuela Zannin,Stefano Gatti,Valentina Vaira,Stefano Ferrero,Luciano Gattinoni +12 more
TL;DR: High strain rate is a risk factor for ventilator-induced pulmonary edema, possibly because it amplifies lung viscoelastic behavior.
Pathophysiological profile of non-ventilated lung injury in healthy female pigs undergoing mechanical ventilation
Elena Spinelli,Anna Damia,F. Damarco,B. Gregori,Federica Occhipinti,Z. Busani,Marco Leali,Michele Battistin,Caterina Lonati,Zhanqi Zhao,Alessandra Maria Storaci,G. Lopez,Valentina Vaira,Stefano Ferrero,Lorenzo Rosso,Stefano Gatti,Tommaso Mauri +16 more
TL;DR: Main pathophysiological alterations associated with NVLI were: extensive lung collapse; very low pulmonary perfusion; high inspiratory airways pressure; and higher concentrations of acute-phase inflammatory cytokines IL-6, IL-1β and TNF-α and of Angiopoietin-2 (a marker of endothelial activation) in the broncho-alveolar lavage.
Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming
Young Chan Chae,Valentina Vaira,Valentina Vaira,M. Cecilia Caino,Hsin Yao Tang,Jae Ho Seo,Andrew V. Kossenkov,Luisa Ottobrini,Luisa Ottobrini,Cristina Martelli,Giovanni Lucignani,Irene Bertolini,Irene Bertolini,Marco Locatelli,Kelly G. Bryant,Jagadish C. Ghosh,Sofia Lisanti,Bonsu Ku,Silvano Bosari,Silvano Bosari,Lucia R. Languino,David W. Speicher,Dario C. Altieri +22 more
TL;DR: Mitochondrial Akt-PDK1 signaling correlates with unfavorable prognostic markers and shorter survival in glioma patients and may provide an "actionable" therapeutic target in cancer.
V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis
Miriam Formica,Alessandra Maria Storaci,Alessandra Maria Storaci,Irene Bertolini,Irene Bertolini,Francesca Carminati,Helene Knævelsrud,Helene Knævelsrud,Valentina Vaira,Valentina Vaira,Thomas Vaccari +10 more
TL;DR: In this paper, the role of autophagy in the pathogenesis of glial tumors in vivo was investigated using an established Drosophila melanogaster model of glioma based on overexpression in larval glial cells of an active human EGFR and of the PI3K homolog Pi3K92E/Dp110.
Epigenetic alterations in cancer and personalized cancer treatment
TL;DR: The role of miRNAs in gene regulation supports their potential as innovative therapeutic strategy and challenges the idea that the epigenetic alterations are 'druggable' sites using specific food components.