Valentina Brunetti
8 Papers
Valentina Brunetti is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 4 publications.
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Papers
The Molecular Heterogeneity of Store-Operated Ca2+ Entry in Vascular Endothelial Cells: The Different roles of Orai1 and TRPC1/TRPC4 Channels in the Transition from Ca2+-Selective to Non-Selective Cation Currents
Francesco Moccia,Valentina Brunetti,Angelica Perna,Germano Guerra,Teresa Soda,Roberto Berra-Romani +5 more
TL;DR: In this article , three distinct currents can mediate store-operated Ca2+ entry (SOCE) in vascular endothelial cells: (1) the Ca2-selective Ca 2+-release activated Ca 2 + current (ICRAC), which is mediated by STIM1 and Orai1; (2) the store-operated nonselective current (ISOC), which was mediated by StIM1, TRPC1, and TRPC4; and (3) the moderately Ca2 + selective, ICRAC-like current (CRAC)-like current, which was mediated by STim1,TRPC1/TRPC4, and ORAi1.
The Emerging Role of N-Methyl-D-Aspartate (NMDA) Receptors in the Cardiovascular System: Physiological Implications, Pathological Consequences, and Therapeutic Perspectives
TL;DR: In this paper , the authors survey the most recent information available regarding the distribution and function of NMDARs within the cardiovascular system, including their involvement in the modulation of heart rate and cardiac rhythm, regulation of arterial blood pressure, in the regulation of cerebral blood flow, and in the blood-brain barrier permeability.
Cracking the Endothelial Calcium (Ca2+) Code: A Matter of Timing and Spacing
TL;DR: The dynamics and spatial distribution of endothelial Ca2+ signals are described to understand how an array of spatially restricted Ca2+.
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Allyl Isothiocianate Induces Ca2+ Signals and Nitric Oxide Release by Inducing Reactive Oxygen Species Production in the Human Cerebrovascular Endothelial Cell Line hCMEC/D3
Roberto Berra-Romani,Valentina Brunetti,Giorgia Pellavio,Teresa Soda,Umberto Laforenza,Giorgia Scarpellino,Francesco Moccia +6 more
TL;DR: In this article , the authors showed that AITC evoked a Ca2+-dependent NO release in the human cerebrovascular endothelial cell line, hCMEC/D3.
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The ion transport, GPCR, and RTK toolkit expression in the human cerebrovascular endothelial cell line, hCMEC/D3: an Omics perspective
Giorgia Scarpellino,Valentina Brunetti,Francesca Scolari,Luca Visentin,G. Biella,Federico Alessandro Ruffinatti,Francesco Moccia +6 more
TL;DR: This study provides a comprehensive transcriptomic analysis of the human blood-brain barrier, identifying a conserved expression of ion transporters and a variable expression of ion channels and receptors, highlighting their roles in ionic homeostasis, barrier integrity, and cerebral blood flow regulation.