Vahap Ulker
13 Papers
Vahap Ulker is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
FasL microgels induce immune acceptance of islet allografts in nonhuman primates
Ji Lei,Maria M. Coronel,Esma S. Yolcu,Hongping Deng,Orlando Grimany-Nuno,Michael D. Hunckler,Vahap Ulker,Zhihong Yang,Kang Mi Lee,Alexander Zhang,Hao Luo,Cole Peters,Zhongliang Zou,Tao Chen,Zhenjuan Wang,Colleen S. McCoy,Ivy A. Rosales,James F. Markmann,Haval Shirwan,Andrés J. García +19 more
TL;DR: This localized immunomodulatory strategy succeeded with unmodified islets and does not require long-term immunosuppression, showing translational potential in β cell replacement for treating type 1 diabetes.
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Prime-Boost Vaccination with SA-4-1BBL Costimulatory Molecule and Survivin Eradicates Lung Carcinoma in CD8+ T and NK Cell Dependent Manner
Abhishek K. Srivastava,Rajesh K. Sharma,Esma S. Yolcu,Vahap Ulker,Kathryn J. MacLeod,Gunes Dinc,Haval Shirwan +6 more
TL;DR: Light is shed on the mechanistic basis of the SA-4-1BBL/SVN subunit vaccine formulation in a lung carcinoma model and the robust therapeutic efficacy of the prime-boost immunization strategy is demonstrated with important clinical implications.
A hydrogel platform for co-delivery of immunomodulatory proteins for pancreatic islet allografts.
Juan D. Medina,Graham F. Barber,Maria M. Coronel,Michael D. Hunckler,Stephen W. Linderman,Michelle J Quizon,Vahap Ulker,Esma S. Yolcu,Haval Shirwan,Andrés J. García +9 more
TL;DR: A hydrogel platform for co-delivering an analog of IL-2, IL- 2D, and FasL-presenting microgels to achieve localized immunotolerance to pancreatic islets by targeting the upregulation of regulatory T cells and effector T cells simultaneously is developed.
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Engineering pancreatic islets with a novel form of thrombomodulin protein to overcome early graft loss triggered by instant blood-mediated inflammatory reaction.
Ali Turan,Lei Zhang,Mohammad Tarique,Vahap Ulker,F. Arguc,Darshan Badal,Esma S. Yolcu,Haval Shirwan +7 more
TL;DR: In this paper , a chimeric form of thrombomodulin with streptavidin (SA-TM) was used for transient display on the surface of islets modified with biotin to mitigate the instant blood-mediated inflammatory reaction (IBMIR), which causes substantial islet loss after intraportal transplantation.
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A novel agonist of 4-1BB costimulatory receptor shows therapeutic efficacy against a tobacco carcinogen-induced lung cancer
Ayse Ece Gulen,Rakesh Rudraboina,Mohammad Tarique,Vahap Ulker,Haval Shirwan,Esma S. Yolcu +5 more
TL;DR: It is suggested that immune checkpoint stimulation can be extended to a number of other cancer types, including breast and prostate cancers, for which improved diagnostics can detect disease at the preneoplastic stage.
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