Vaea Richard de Soultrait
Centre national de la recherche scientifique
10 Papers
229 Citations
Vaea Richard de Soultrait is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Integrase & Yeast. The author has an hindex of 10, co-authored 10 publications.
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Papers
Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60.
Vincent Parissi,Christina Calmels,Vaea Richard de Soultrait,Anne Caumont,Michel Fournier,Stéphane Chaignepain,Simon Litvak +6 more
TL;DR: Yeast lethality induced by HIV-1 IN was abolished when a mutated HSP60 was coexpressed, therefore suggesting that both proteins interact in vivo, and strong evidences suggest that this lethality is linked to IN activity in infected human cells where integration requires the cleavage of genomic DNA.
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A novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase.
Vaea Richard de Soultrait,Anne Caumont,Vincent Parissi,Nelly Morellet,Michel Ventura,Christine Lenoir,Simon Litvak,Michel Fournier,Bernard P. Roques +8 more
TL;DR: This work isolated a 33-mer peptide that inhibited both in vitro IN activities and showed a significant antiviral effect when assayed on HIV-1 infected human cells, suggesting this potentially important short lead peptide may not only be helpful to design new anti-HIV agents, but also could prove very useful in further studies of the structural and functional characteristics of HIV- 1 IN.
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HIV-1 integrase interacts with yeast microtubule-associated proteins
Vaea Richard de Soultrait,Anne Caumont,Pascal Durrens,Christina Calmels,Vincent Parissi,Patricia Recordon,Elisabeth Bon,Cécile Desjobert,Laura Tarrago-Litvak,Michel Fournier +9 more
TL;DR: The identification of components of the microtubule network associated with IN suggest a role of this complex in the transport of HIV-1 IN present in the PIC to the nucleus, as already described for other human viruses.
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Inactivation of the SNF5 transcription factor gene abolishes the lethal phenotype induced by the expression of HIV-1 integrase in yeast.
Vincent Parissi,Anne Caumont,Vaea Richard de Soultrait,Charles-Henri Dupont,Sergio Pichuantes,Simon Litvak +5 more
TL;DR: The effect of the inactivation of the gene encoding for SNF5, a yeast transcription factor homologous to Ini1, on the lethality induced by the expression of HIV-1 IN in yeast suggests that this factor may be important for IN activity in infected cells.
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Selection of amino acid substitutions restoring activity of HIV-1 integrase mutated in its catalytic site using the yeast Saccharomyces cerevisiae.
Vincent Parissi,Anne Caumont,Vaea Richard de Soultrait,Christina Calmels,Sergio Pichuantes,Simon Litvak,Charles-Henri Dupont +6 more
TL;DR: The hypothesis that explains the lethal effect as a consequence of the nuclear damage caused by wild-type IN in yeast cells is supported and the data indicate that the yeast lethal assay can be used as a tool to study the retroviral integration mechanism in a cellular context and to select specific inhibitors.
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