Background Mifepristone and a prostaglandin have been used successfully to terminate pregnancy in Europe and China. We report the results of a large U.S. study of mifepristone and misoprostol in women with pregnancies of up to nine weeks' duration. Methods We administered 600 mg of mifepristone and then 400 μg of misoprostol two days later to 2121 women seeking termination of their pregnancies at 17 centers. The women were observed for four hours after the administration of misoprostol and returned on day 15 for final assessment. Results Two thousand fifteen women completed the final assessment. Among them, pregnancy was terminated in 762 of the 827 women pregnant for <49 days (92 percent), 563 of the 678 women pregnant for 50 to 56 days (83 percent), and 395 of the 510 women pregnant for 57 to 63 days (77 percent) (P<0.001). Termination occurred within 4 hours after the administration of misoprostol in 49 percent of the women and within 24 hours in 75 percent. Failures, defined as cases requiring surgica...

Early pregnancy termination with mifepristone and misoprostol in the United States.

Factors affecting the outcome of early medical abortion: a review of 4132 consecutive cases

Termination of pregnancy has been practiced since antiquity. Although many societies accept this practice, some reject it, and it is sometimes even considered a crime. The most widely used methods for terminating pregnancy early in the first trimester are surgical, primarily vacuum aspiration, which is safer and less painful than dilation and curettage. An estimated 26 million pregnancies are terminated legally each year throughout the world, and 20 million are terminated illegally, with more than 78,000 deaths.1 A safe medical method would save many lives. In the United States, where abortion is legal and is performed by trained personnel, the . . .

https://www.nejm.org/doi/pdf/10.1056/NEJM200003303421307?listPDF=true

Medical termination of pregnancy.

Mifepristone: bioavailability, pharmacokinetics and use-effectiveness.

The efficacy of medical abortion: a meta-analysis.

The efficacy and tolerance of mifepristone and prostaglandin in termination of pregnancy of less than 63 days gestation; UK multicentre study—Final results

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The efficacy and tolerance of mifepristone and prostaglandin in termination of pregnancy of less than 63 days gestation; UK multicentre study—Final results