V.R. King
Queen Mary University of London
24 Papers
379 Citations
V.R. King is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Spinal cord & Spinal cord injury. The author has an hindex of 21, co-authored 24 publications.
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Papers
Chondroitinase ABC promotes functional recovery after spinal cord injury
Elizabeth J. Bradbury,Lawrence D. F. Moon,Lawrence D. F. Moon,Reena J Popat,V.R. King,GS Bennett,Preena N. Patel,James W. Fawcett,Stephen B. McMahon +8 more
TL;DR: It is demonstrated that CSPGs are important inhibitory molecules in vivo and suggested that their manipulation will be useful for treatment of human spinal injuries.
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Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity
Fiona E. Holmes,Sally Mahoney,V.R. King,Andrea Bacon,Niall C. H. Kerr,Vassilis Pachnis,Rory A. J. Curtis,John V. Priestley,David Wynick +8 more
TL;DR: A critical role is identified for galanin in the development and regeneration of sensory neurons after crush injury to the sciatic nerve with associated long-term functional deficits in mice carrying a loss-of-function mutation.
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Mats made from fibronectin support oriented growth of axons in the damaged spinal cord of the adult rat.
TL;DR: The results indicate that FN mats provide a substrate that is permissive for robust oriented axonal growth in the damaged spinal cord, and that this growth is supported by Schwann cells.
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Changes in truncated trkB and p75 receptor expression in the rat spinal cord following spinal cord hemisection and spinal cord hemisection plus neurotrophin treatment
TL;DR: This study is the first to show changes in truncated trkB receptor expression that extend beyond the site of a spinal cord lesion and is one of thefirst to show that BDNF and NT-3 affect Schwann cells and/or p75 expression following spinal cord damage.
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Characterization of non-neuronal elements within fibronectin mats implanted into the damaged adult rat spinal cord.
TL;DR: Axonal ingrowth and integration of the FN mats is probably due to the ability of FN mats to support and organize infiltration of Schwann cells and deposition of laminin, which is likely to be important in the design of biomaterial bridges for CNS regeneration.
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