We quantified the spatial distribution of presumed ganglion cells and displaced amacrine cells in unstained whole mounts of six young normal human retinas whose photoreceptor distributions had previously been characterized. Cells with large somata compared to their nuclei were considered ganglion cells; cells with small somata relative to their nuclei were considered displaced amacrine cells. Within the central area, ganglion cell densities reach 32,000-38,000 cells/mm2 in a horizontally oriented elliptical ring 0.4-2.0 mm from the foveal center. In peripheral retina, densities in nasal retina exceed those at corresponding eccentricities in temporal retina by more than 300%; superior exceeds inferior by 60%. Displaced amacrine cells represented 3% of the total cells in central retina and nearly 80% in the far periphery. A twofold range in the total number of ganglion cells (0.7 to 1.5 million) was largely explained by a similar range in ganglion cell density in different eyes. Cone and ganglion cell number were not correlated, and the overall cone:ganglion cell ratio ranged from 2.9 to 7.5 in different eyes. Peripheral cones and ganglion cells have different topographies, thus suggesting meridianal differences in convergence onto individual ganglion cells. Low convergence of foveal cones onto individual ganglion cells is an important mechanism for preserving high resolution at later stages of neural processing. Our improved estimates for the density of central ganglion cells allowed us to ask whether there are enough ganglion cells for each cone at the foveal center to have a direct line to the brain. Our calculations indicate that 1) there are so many ganglion cells relative to cones that a ratio of only one ganglion cell per foveal cone would require fibers of Henle radiating toward rather than away from the foveal center; and 2) like the macaque, the human retina may have enough ganglion cells to transmit the information afforded by closely spaced foveal cones to both ON- and OFF-channels. Comparison of ganglion cell topography with the visual field representation in V1 reveals similarities consistent with the idea that cortical magnification is proportional to ganglion cell density throughout the visual field.

Topography of ganglion cells in human retina.

http://www.sscnet.ucla.edu/polisci/faculty/chwe/austen/kobayashi2001.pdf

Unique morphology of the human eye and its adaptive meaning: comparative studies on external morphology of the primate eye.

We have used antibodies specific to either the red/green-or blue-sensitive cones in order to compare their ratio and distributions to that of the rods in the retinae of 3 primate species that differ in their capacity for color vision. We have found that the monoclonal antibody CSA-1 (Johnson and Hageman, 1988) and the polyclonal antibody 4942A, specific to the red- and green-cone opsin (Lerea et al., 1989), applied to retinal whole-mounts labeled approximately 90% of all cones in the diurnal Old-World rhesus monkey (Macaca mulatta) and all of the cones in the nocturnal New-World owl monkey (Aotus trivirgatus) and nocturnal prosimian bushbaby (Galago garnetti). The polyclonal antibody 108B, specific to the blue-cone opsin (Lerea et al., 1989), labeled about 10% of the cones across the entire surface of the rhesus monkey retina, but failed to label any cones in the retina of the 2 nocturnal species. Only the retina of the rhesus monkey possessed an all-cone foveola in which the density of cone inner segments was 17-fold greater than that in the fovea of the owl monkey or bushbaby retina. Surprisingly, the density of cones per unit area outside of the fovea was comparable in all 3 species. Rod density in the dorsal retina was elevated in all animals examined, but was 2-3 times greater in the nocturnal species than in the rhesus monkey retina. Application of the photoreceptor-class-specific antibodies may provide further insights into the evolution and development of wavelength sensitivity in the retina, as well as enhance our understanding of normal and abnormal color vision in humans.

https://www.jneurosci.org/content/jneuro/10/10/3390.full.pdf

Distribution of photoreceptor subtypes in the retina of diurnal and nocturnal primates

Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina

We have measured the amount of cortical space activated by differently oriented gratings in 25 adult ferrets by optical imaging of intrinsic signal. On average, 7% more area of the exposed visual cortex was preferentially activated by vertical and horizontal contours than by contours at oblique angles. This anisotropy may reflect the real-world prevalence of contours in the cardinal axes and could explain the greater sensitivity of many animals to vertical and horizontal stimuli.

https://www.pnas.org/content/pnas/95/5/2621.full.pdf

Unequal representation of cardinal and oblique contours in ferret visual cortex

The size and topographic arrangement of retinal ganglion cells in the galago

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The size and topographic arrangement of retinal ganglion cells in the galago