V. E. Gmiro
Russian Academy
10 Papers
22 Citations
V. E. Gmiro is an academic researcher from Russian Academy. The author has contributed to research in topics: AMPA receptor & Anticonvulsant. The author has an hindex of 5, co-authored 10 publications.
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Papers
Comparative study of preventive and therapeutic effects of IEM-1966 and memantine in rats with experimental allergic encephalomyelitis.
TL;DR: Preventive and therapeutic effects of memantine and IEM-1966, a blocker of both NMDA-and GluR1 AMPA-receptors, on the model of acute experimental allergic encephalomyelitis reduced the severity of neurological disturbances and duration of the disease.
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Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats.
TL;DR: Intramuscular injection of NBQX, a selective blocker of AMPA receptors (10 mg/kg), produced more pronounced anticonvulsant and neuroprotective effects: it prevented generalized kainate seizures and chronic kainates lethality in 100 and 80% rats, respectively, however, even the high dose ofNBQX prevented the clonic kainATE seizures only in 30% rats.
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Combined blockade of α3β4 nicotinic acetylcholine receptors and GluR1 AMPA receptors in rats prevents kainate-induced tonic-clonic seizures
S. E. Serdyuk,V. E. Gmiro +1 more
TL;DR: Intramuscular injection of IEM-1754, a blocker of cerebral GluR1 AMPA receptors, in doses of 0.5–3.0 mg/kg decreased the incidence of kainate-induced tonic-clonic seizures and mortality rate by 2.7–4 times.
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Epinephrine potentiates the analgesic and antidepressant effects of amitriptyline as a result of stimulation of the gastric mucosal afferents.
S. E. Serdyuk,V. E. Gmiro +1 more
TL;DR: Combined injection of amitriptyline with epinephrine in the threshold doses (ineffective if used alone), 1/10 and 1/30 minimum effective doses, respectively, leads to the development of the maximum analgesic and antidepressant effect, but causes no sedative side effect.
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Epinephrine potentiates antipsychotic, but not cataleptogenic effect of haloperidol in rats.
V. E. Gmiro,S. E. Serdyuk +1 more
TL;DR: In this paper, a rat model of schizophrenia was used to demonstrate that combined intramuscular injection of haloperidol and epinephrine in the threshold doses, ineffective in monotherapy, causes the maximum antipsychotic effect but not catalepsy.
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