7 Papers
83 Citations
V. Brechler is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Glucagon & Pertussis toxin. The author has an hindex of 5, co-authored 7 publications.
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Papers
Inhibition by glucagon of the cGMP-inhibited low-Km cAMP phosphodiesterase in heart is mediated by a pertussis toxin-sensitive G-protein.
TL;DR: The results confirm that two mechanisms mediate the action of glucagon in heart: one is the activation of adenylylcyclase through Gs, and the other relies on the inhibition of the membrane-bound low-Km CGI-PDE, via a pertussis toxin-sensitive G-protein.
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Activation of Na+/Ca2+ exchange by adenosine in ewe heart sarcolemma is mediated by a pertussis toxin-sensitive G protein
TL;DR: The results suggest that A1 subclass receptors coupled to a pertussis toxin-sensitive G protein mediate the activation of Na+/Ca2+ exchange activity by adenosine, which is antagonistic toward cyclic AMP.
37
Hormonal and Non-Hormonal Regulation of Ca2+ Current and Adenylate Cyclase in Cardiac Cells
Rodolphe Fischmeister,Pierre-François Méry,Alvin Shrier,Alvin Shrier,Catherine Pavoine,V. Brechler,Françoise Pecker +6 more
- 01 Jan 1990
TL;DR: The effects of β-adrenergic agonists on ICa were mimicked by external application of cAMP, its analogues or phosphodiesterase inhibitors, forskolin, or the catalytic subunit of camping-dependent protein kinase (PKA), which may play only a minor role in the physiological response to noradrenaline.
3
Glucagon-(19-29) exerts a biphasic action on the liver plasma membrane Ca2+ pump which is mediated by G proteins.
Sophie Lotersztajn,Catherine Pavoine,V. Brechler,B. Roche,M. Dufour,Dung Le-Nguyen,Dominique Bataille,Françoise Pecker +7 more
TL;DR: It is concluded that glucagon-(19-29) can exert a biphasic effect on the Ca2+ pump which is mediated by G protein(s) sensitive to cholera toxin.