V. Brandalise
University of São Paulo
4 Papers
V. Brandalise is an academic researcher from University of São Paulo. The author has contributed to research in topics: Muscular dystrophy & Cell therapy. The author has an hindex of 4, co-authored 4 publications.
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Papers
Human multipotent adipose-derived stem cells restore dystrophin expression of Duchenne skeletal-muscle cells in vitro.
Natássia M. Vieira,V. Brandalise,Eder Zucconi,Tatiana Jazedje,Mariane Secco,Viviane Abreu Nunes,Bryan E. Strauss,Mariz Vainzof,Mayana Zatz +8 more
TL;DR: ASCs (adipose‐derived stem cells) are able to restore dystrophin expression in the muscles of mdx (X‐linked muscular dystrophy) mice, however, the outcome when these cells interact with human dystrophic muscle is still unknown.
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Isolation, characterization, and differentiation potential of canine adipose-derived stem cells.
TL;DR: Like human lipoaspirate, canine adipose tissue may also contain multipotent cells and represent an important stem cell source both for veterinary cell therapy as well as preclinical studies.
Human adipose-derived mesenchymal stromal cells injected systemically into GRMD dogs without immunosuppression are able to reach the host muscle and express human dystrophin.
Natássia M. Vieira,M. Valadares,Eder Zucconi,Mariane Secco,Carlos Roberto Bueno,V. Brandalise,A. Assoni,J. Gomes,V. Landini,Telma Gonçalves Carneiro Spera de Andrade,Heloísa Vasconcellos Amaral Caetano,Mariz Vainzof,Mayana Zatz +12 more
TL;DR: It is demonstrated that injecting a huge quantity of human mesenchymal cells in a large-animal model, without immunosuppression, is a safe procedure, which may have important applications for future therapy in patients with different forms of muscular dystrophies.
SJL Dystrophic Mice Express a Significant Amount of Human Muscle Proteins Following Systemic Delivery of Human Adipose-Derived Stromal Cells Without Immunosuppression
Natássia M. Vieira,Carlos Roberto Bueno,V. Brandalise,Luciana Vieira de Moraes,Eder Zucconi,Mariane Secco,Miriam F. Suzuki,Maristela M. de Camargo,Paolo Bartolini,Patricia Chakur Brum,Mariz Vainzof,Mayana Zatz +11 more
TL;DR: It is shown for the first time that hASCs are not rejected after systemic injection even without immunosuppression, are able to fuse with the host muscle, express a significant amount of human muscle proteins, and improve motor ability of injected animals.