Uwe Leimer
Ludwig Maximilian University of Munich
9 Papers
50 Citations
Uwe Leimer is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Presenilin & Senile plaques. The author has an hindex of 7, co-authored 7 publications.
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Papers
Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain
Philipp J. Kahle,Manuela Neumann,Laurence Ozmen,Veronika Müller,Helmut Jacobsen,Alice Schindzielorz,Masayasu Okochi,Uwe Leimer,Herman van der Putten,Alphonse Probst,Elisabeth Kremmer,Hans A. Kretzschmar,Christian Haass +12 more
TL;DR: The Parkinson's disease-associated human mutant [A30P]αSYN was found to colocalize with βSYN and synaptophysin in synapses of transgenic mouse brain, however, in addition to their normal presynaptic localization, transgenic wild-type and [A 30P] αSYN abnormally accumulated in neuronal cell bodies and neurites throughout the brain.
677
Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
TL;DR: This work has shown that a knock out of PS1 in mice leads to an embryonic lethal phenotype similar to that of mice lacking Notch, and may suggest that PS1 could be the γ-secretase itself, exhibiting the properties of a novel aspartyl protease.
72
Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?
TL;DR: The authors thank H. Mori for the aSYN immunohistochemistry photomicrographs and M. Okochi for critically reviewing the manuscript.
35
Proteolytic processing of Alzheimer’s disease associated proteins
Christian Haass,Jürgen Grünberg,Anja Capell,Christine Wild-Bode,Uwe Leimer,Jochen Walter,Tsuneo Yamazaki,I. Ihara,I. Zweckbronner,C. Jakubek,Ralf Baumeister +10 more
TL;DR: It is demonstrated that PS proteins are involved in NOTCH signaling FAD causing mutations interfere with the biological function of PS proteins in NotCH signaling.
18
Use of collagenase to isolate adipose tissue-derived stem cells – substantial manipulation or not?
TL;DR: The use of collagenase does not substantially impair central in vitro characteristics and functions of human adipose tissue-derived stem cells and using collagenase compared to mechanical isolation did not alter the expression of typical surface markers of ADSCs.