Uwe Gerstenmaier
4 Papers
2 Citations
Uwe Gerstenmaier is an academic researcher. The author has contributed to research in topics: dNaM & Buccal swab. The author has an hindex of 3, co-authored 4 publications.
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Papers
Epigenetic age predictions based on buccal swabs are more precise in combination with cell type-specific DNA methylation signatures.
Monika Eipel,Felix Mayer,Tanja Arent,Marcelo R.P. Ferreira,Carina Birkhofer,Uwe Gerstenmaier,Ivan G. Costa,Stefanie Ritz-Timme,Wolfgang Wagner +8 more
- 21 Feb 2017
TL;DR: It is demonstrated that the cellular composition in buccal swab samples can be determined by DNAm at two cell type-specific CpGs to improve epigenetic age predictions.
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DNA methylation in PRDM8 is indicative for dyskeratosis congenita
Carola I. Weidner,Qiong Lin,Carina Birkhofer,Uwe Gerstenmaier,Andrea Kaifie,Martin Kirschner,Heiko Bruns,Stefan Balabanov,Arne Trummer,Clemens Stockklausner,Britta Höchsmann,Hubert Schrezenmeier,Marcin W. Wlodarski,Jens Panse,Tim H. Brümmendorf,Fabian Beier,Wolfgang Wagner +16 more
TL;DR: Aberrant hypermethylation is particularly observed in PRDM8 and this may support identification and classification of bone marrow failure syndromes, albeit age-associated DNAm patterns are not generally accelerated.
Leukocyte counts based on site-specific DNA methylation analysis
Joana Frobel,Tanja Božić,Michael Lenz,Michael Lenz,Peter Uciechowski,Yang Han,Reinhild Herwartz,Klaus Strathmann,Susanne Isfort,Jens Panse,André Esser,Carina Birkhofer,Uwe Gerstenmaier,Thomas Kraus,Lothar Rink,Steffen Koschmieder,Wolfgang Wagner +16 more
TL;DR: The “Epi-Blood-Count” facilitates robust and cost effective analysis of blood counts for clinical application and describes a new approach for absolute quantification of cell numbers based on a non-methylated reference DNA.
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Leukocyte Counts Based on DNA Methylation at Individual Cytosines.
Joana Frobel,Tanja Božić,Michael Lenz,Michael Lenz,Peter Uciechowski,Yang Han,Reinhild Herwartz,Klaus Strathmann,Susanne Isfort,Jens Panse,André Esser,Carina Birkhofer,Uwe Gerstenmaier,Thomas Kraus,Lothar Rink,Steffen Koschmieder,Wolfgang Wagner +16 more
TL;DR: White blood cell counts can be reliably determined by site-specific DNAm analysis and is applicable to very small blood volumes and frozen samples, and it allows for more standardized and cost-effective analysis in clinical application.