Ute Scheffer
Goethe University Frankfurt
24 Papers
172 Citations
Ute Scheffer is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: RNA & Oligonucleotide. The author has an hindex of 11, co-authored 23 publications.
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Papers
A peptide template as an allosteric supramolecular catalyst for the cleavage of phosphate esters.
Alessandro Scarso,Ute Scheffer,Michael W. Göbel,Quirinus B. Broxterman,Bernard Kaptein,Fernando Formaggio,Claudio Toniolo,Paolo Scrimin +7 more
TL;DR: It is suggested that the opposite behavior of the catalyst induced by ZnII is associated with the change of conformation of the Tren platform, and consequently of the relative spatial disposition of the three linked peptides, that occurs after binding of the metal ion.
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Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome.
Sridhar Sreeramulu,Christian Richter,Hannes Berg,Maria Alexandra Wirtz Martin,Betül Ceylan,Tobias Matzel,Jennifer Adam,Nadide Altincekic,Kamal Azzaoui,Jasleen Kaur Bains,Marcel J. J. Blommers,Jan Ferner,Boris Fürtig,Michael W. Göbel,J Tassilo Grün,Martin Hengesbach,Katharina F. Hohmann,Daniel Hymon,Bozana Knezic,Jason N Martins,Klara R. Mertinkus,Anna Niesteruk,Stephen A. Peter,Dennis J. Pyper,Nusrat S. Qureshi,Nusrat S. Qureshi,Ute Scheffer,Andreas Schlundt,Robbin Schnieders,Elke Stirnal,Alexey Sudakov,Alix Tröster,Jennifer Vögele,Anna Wacker,Julia E. Weigand,Julia Wirmer-Bartoschek,Jens Wöhnert,Harald Schwalbe +37 more
TL;DR: In this paper, the authors performed an NMR-based screening of a poised fragment library of 768 compounds for binding to the RNA of SARS-CoV-2, employing three different 1H-based 1D NMR binding assays.
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Scaffold hopping by "fuzzy" pharmacophores and its application to RNA targets.
Yusuf Tanrikulu,Manuel Nietert,Ute Scheffer,Ewgenij Proschak,Kristina Grabowski,Petra Schneider,Markus Weidlich,Michael Karas,Michael W. Göbel,Gisbert Schneider +9 more
TL;DR: The successful application of the “fuzzy” pharmacophore method LIQUID (“ligand-based quantification of interaction distributions”) to finding novel RNA ligand scaffolds and new inhibitors of in vitro protein expression is presented.
New inhibitors of the Tat-TAR RNA interaction found with a "fuzzy" pharmacophore model.
TL;DR: A “fuzzy” pharmacophore approach (SQUID) and an alignment‐free Pharmacophore method (CATS3D) are used to carry out virtual screening of a vendor database of small molecules and to perform “scaffold‐hopping” to retrieve novel scaffolds for RNA‐binding molecules capable of inhibiting the Tat–TAR interaction.
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Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR.
Mirco Zeiger,Sebastian Stark,Elisabeth Kalden,Bettina Ackermann,Jan Ferner,Ute Scheffer,Fatemeh Shoja-Bazargani,Veysel Erdel,Harald Schwalbe,Michael W. Göbel +9 more
TL;DR: The results encourage investigations of dimeric ligands built from two copies of compound 22 or related heterocycles, and 1,7-Diaminoisoquinoline 17 and 2,4,6-triaminoquinazoline 22 have been further characterized by NMR titrations with TAR RNA.
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