Ute Schaeper
16 Papers
12 Citations
Ute Schaeper is an academic researcher. The author has contributed to research in topics: Medicine & Gene silencing. The author has an hindex of 7, co-authored 16 publications.
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Papers
Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models
Ansgar Santel,Manuela Aleku,Nadine Röder,Kristin Möpert,Birgit Durieux,Oliver Janke,Oliver Keil,Jens Endruschat,Sibylle Dames,Christian Lange,Mona Eisermann,Kathrin Löffler,Melanie Fechtner,Gerald Fisch,Christiane Vank,Ute Schaeper,Klaus Giese,Jörg Kaufmann +17 more
TL;DR: Intravenous administration of Atu027 prevents pulmonary metastasis and provides evidence that an increase in VE-cadherin protein levels as a downstream result of PKN3 target gene inhibition may change endothelial function, resulting in reduced colonization and micrometastasis formation.
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Delivery of Therapeutic siRNA to the Lung Endothelium via Novel Lipoplex Formulation DACC
Volker Fehring,Ute Schaeper,Katharina Ahrens,Ansgar Santel,Oliver Keil,Mona Eisermann,Klaus Giese,Jörg Kaufmann +7 more
TL;DR: Development and in vivo characterization of a novel siRNA delivery system (DACC lipoplex) suitable for modulating target gene expression specifically in the lung vasculature and repeated treatment with DACC/siRNA(CD31) reduced formation of lung metastases and increased life span in a mouse model of experimental lung metastasis.
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CLIC4/Arf6 Pathway
Vahitha B. Abdul-Salam,Giusy Russomanno,Chen Chien-Nien,Abdul S. Mahomed,Luke A. Yates,Martin R. Wilkins,Lan Zhao,Magdalena Gierula,Oliver Dubois,Ute Schaeper,Jens Endruschat,Beata Wojciak-Stothard +11 more
TL;DR: In this article, increased expression of CLIC4 (chloride intracellular channel 4) is a feature of endothelial dysfunction in pulmonary arterial hypertension, but its role in disease pathology is not full.
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Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH
Jorge Simón,Naroa Goikoetxea-Usandizaga,Marina Serrano-Macia,David Fernández-Ramos,Diego Saenz de Urturi,Jessica J. Gruskos,Pablo Fernández-Tussy,Sofia Lachiondo-Ortega,Irene González-Recio,Rubén Rodríguez-Agudo,Virginia Gutiérrez-de-Juan,Begoña Rodríguez-Iruretagoyena,Marta Varela-Rey,Paula Giménez-Mascarell,Maria Mercado-Gómez,Beatriz Gomez-Santos,C. Fernández-Rodríguez,Fernando Lopitz-Otsoa,Maider Bizkarguenaga,Sibylle Dames,Ute Schaeper,Franz Martín,Guadalupe Sabio,Paula Iruzubieta,Javier Crespo,Patricia Aspichueta,Kevan H.-Y. Chu,Daniela Buccella,César Martín,Teresa C. Delgado,Luis Alfonso Martínez-Cruz,María L. Martínez-Chantar +31 more
TL;DR: In this paper, the authors proposed MINECO for the Severo Ochoa Excellence Accreditation to CIC bioGUNE (SEV-2016-0644), which is funded by the Instituto de Salud Carlos III.
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Foxf1 siRNA delivery to hepatic stellate cells by DBTC lipoplex formulations ameliorates fibrosis in livers of bile duct ligated mice.
Kerstin Abshagen,Malte Brensel,Berit Genz,Kira Roth,Maria Thomas,Volker Fehring,Ute Schaeper,Brigitte Vollmar +7 more
TL;DR: It is suggested that Foxf1 may serve as a target gene to disrupt progression of liver fibrosis and DBTC might provide a potentially feasible and effective tool for HSC-specific delivery of therapeutic RNA.
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