Urs Eiholzer
University of Zurich
65 Papers
644 Citations
Urs Eiholzer is an academic researcher from University of Zurich. The author has contributed to research in topics: Medicine & Lean body mass. The author has an hindex of 26, co-authored 64 publications. Previous affiliations of Urs Eiholzer include University of California, Irvine & University Hospital of Lausanne.
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Papers
Male hypogonadism caused by homozygous deletion of exon 10 of the luteinizing hormone (LH) receptor: differential action of human chorionic gonadotropin and LH.
TL;DR: The response to hCG indicates a possible dual mechanism of hormone binding and signal transduction for hCG and LH on a LHR that lacks exon 10, which represents the clinical counterpart of the normal male marmoset monkey (Callithrix jacchus), in which the expressed LHR lacksExon 10 in toto.
Hypothalamic and gonadal components of hypogonadism in boys with Prader-Labhart- Willi syndrome.
Urs Eiholzer,Dagmar l'Allemand,Valentin Rousson,Michael Schlumpf,Theo Gasser,Jürg Girard,Annette Grüters,Manuela Simoni +7 more
TL;DR: Children with PWS display a specific form of combined hypothalamic (low LH) and peripheral (low inhibin B and high FSH) hypogonadism, suggesting a primary defect in Sertoli and/or germ cell maturation or an early germ cell loss.
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Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies
Roland Pfaeffle,Chad S. Hunter,Jesse J. Savage,Mario Durán-Prado,Rachel D. Mullen,Zachary P. Neeb,Urs Eiholzer,Volker Hesse,Nadine G. Haddad,Heike Stobbe,Werner F. Blum,Johannes F. W. Weigel,Simon J. Rhodes +12 more
TL;DR: The range of phenotypes associated with LHX4 gene mutations is extended and three novel exonic mutations in the gene are described, a relatively rare cause of combined pituitary hormone deficiency.
Low insulin, IGF-I and IGFBP-3 levels in children with Prader-Labhart-Willi syndrome.
TL;DR: Levels of insulin, IGF-I, but also IGFBP-3 levels are low and fasting insulin levels even very low, suggesting a growth hormone deficiency in Prader-Labhart-Willi syndrome children, which is typically obese.
103
Treatment with human growth hormone in patients with Prader-Labhart-Willi syndrome reduces body fat and increases muscle mass and physical performance.
Urs Eiholzer,R. Gisin,C. Weinmann,S. Kriemler,Hans C. Steinert,Toni Torresani,Milo Zachmann,Andrea Prader +7 more
TL;DR: Growth hormone treatment in Prader-Labhart-Willi syndrome led to dramatic changes: distinct increase in growth velocity, height and muscle mass, as well as an improvement in physical performance.