Urban Hellman
Umeå University
45 Papers
206 Citations
Urban Hellman is an academic researcher from Umeå University. The author has contributed to research in topics: Transthyretin & Amyloidosis. The author has an hindex of 15, co-authored 41 publications.
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Papers
Cardiomyocyte Microvesicles Contain DNA/RNA and Convey Biological Messages to Target Cells
TL;DR: The study suggests that microvesicles/exosomes released from cardiomyocytes, where it is proposed that exosomes derived from carduomyocytes could be denoted “cardiosomes”, can be involved in a metabolic course of events in target cells by facilitating an array of metabolism-related processes including gene expression changes.
Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population
Urban Hellman,Flora Alarcon,Hans-Erik Lundgren,Ole B. Suhr,Catherine Bonaïti-Pellié,Violaine Planté-Bordeneuve +5 more
TL;DR: The penetrance estimates were low, i.e. 1.7% and 22% at age 30 and 60 years, respectively, and far from complete by age 90 years, and this is important information for the genetic counseling and treatment of Swedish FAP patients and their families.
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Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1
Anna Carlsson,Lars Forsgren,P-O Nylander,Urban Hellman,Kristina Forsman-Semb,Gösta Holmgren,Dan Holmberg,Monica Holmberg +7 more
TL;DR: A genomewide screen was performed in a large family from northern Sweden to find novel susceptibility genes for familial migraine with and without aura, and evidence of linkage was obtained on chromosome 6p12.2-p21.1.
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Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes.
Nina Gennebäck,Urban Hellman,Linus Malm,Göran Larsson,Gunnar Ronquist,Anders Waldenström,Stellan Mörner +6 more
TL;DR: It is shown that the mode of stimulation of parental cells affects the characteristics of exosome released, and there is a difference in mRNA content between exosomes derived from cultured cardiomyocytes stimulated, or not stimulated, with growth factors.
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Presence of hyaluronan in lung alveoli in severe Covid-19 - an opening for new treatment options?
Urban Hellman,Mats G. Karlsson,Anna Engström-Laurent,Sara Cajander,Luiza Dorofte,Clas Ahlm,Claude Laurent,Anders Blomberg +7 more
TL;DR: This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2.
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